PPARGC1A
PPARGC1A，即過(guò)氧化物酶體增殖物激活受體γ共激活劑1α，別名PGC-1α、PPRC1α。它是一種轉(zhuǎn)錄共激活因子，主要在心臟、骨骼肌、肝臟和腎臟等組織中高表達(dá)，而在大腦和胰腺中表達(dá)水平較低，在腸道和白色脂肪組織中表達(dá)水平非常低。PPARGC1A的作用機(jī)制涉及與多種核受體和轉(zhuǎn)錄因子相互作用，增強(qiáng)其轉(zhuǎn)錄活性，調(diào)節(jié)線粒體生物發(fā)生、能量代謝和熱生成等過(guò)程。它參與晝夜節(jié)律和能量代謝的整合，激活與代謝相關(guān)的基因，如PDK4和PEPCK，調(diào)控生物鐘基因的振蕩表達(dá)。PPARGC1A是適應(yīng)性產(chǎn)熱和代謝重編程的關(guān)鍵調(diào)控因子，其表達(dá)水平受長(zhǎng)期能量供應(yīng)的控制，且在肥胖和高脂飲食環(huán)境下表達(dá)水平下降。PPARGC1A的功能異常與多種代謝性疾病有關(guān)，是治療II型糖尿病、肥胖癥、心肌病等代謝紊亂的潛在靶點(diǎn)。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E11761h
規(guī)格：96T/48T
靈敏度：31.25 pg/mL
檢測(cè)范圍：125 pg/mL-8000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
PPARGC1A Antibodies
PPARGC1A for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA042134 | PPARGC1A Antibody | Human,Mouse,Rat | ELISA |
PPARGC1A Proteins
PPARGC1A Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP529139MO CSB-EP529139MO CSB-BP529139MO CSB-MP529139MO CSB-EP529139MO-B |
Recombinant Mouse Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (Ppargc1a) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPARGC1A Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP772944BO CSB-EP772944BO CSB-BP772944BO CSB-MP772944BO CSB-EP772944BO-B |
Recombinant Bovine Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPARGC1A Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP774721PI CSB-EP774721PI CSB-BP774721PI CSB-MP774721PI CSB-EP774721PI-B |
Recombinant Pig Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPARGC1A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP871382HU CSB-BP871382HU CSB-MP871382HU CSB-EP871382HU-B |
Recombinant Human Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP871382HUa0 | Recombinant Human Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) | E.coli |
| CSB-EP871382HU | Recombinant Human Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) | E.coli |
PPARGC1A Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP889889RA CSB-EP889889RA CSB-BP889889RA CSB-MP889889RA CSB-EP889889RA-B |
Recombinant Rat Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (Ppargc1a) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPARGC1A ELISA Kit
PPARGC1A ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11761h | Human peroxisome proliferative activated receptor gama coactivator 1 alpha,PPARGC1 ELISA Kit | serum, plasma, cell culture supernates, cell lysates | 31.25 pg/mL |
PPARGC1A ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL018425MO | Mouse Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) ELISA kit | serum, plasma, tissue homogenates | 5.86 pg/mL |
