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PEX19

PEX19,即過氧化物酶體生物發(fā)生因子19,別名PXF、HK33、PMP1、PMPI、PXMP1、PBD12A、D1S2223E。它在人類中位于1q23.2染色體上,編碼的蛋白質(zhì)是早期過氧化物酶體生物發(fā)生所必需的。PEX19的作用機(jī)制包括與Pex3的相互作用以及與含膜過氧化物酶體靶向信號(hào)(mPTS)的PMPs的相互作用。PEX19的N末端和C末端構(gòu)建體分別負(fù)責(zé)與Pex3和PMPs的結(jié)合。Pex25對(duì)于過氧化物酶體與CTC變體的形成至關(guān)重要,其過表達(dá)增強(qiáng)了它們與Pex3的相互作用,并有助于NTC和CTC Pex19變體的生長(zhǎng)。PEX19基因的缺陷可能導(dǎo)致Zellweger綜合征(ZWS)以及過氧化物酶體生物發(fā)生障礙互補(bǔ)組14(PBD-CG14),顯示了其在人類健康中的重要性。

熱銷產(chǎn)品

Recombinant Human Peroxisomal biogenesis factor 19 (PEX19) (Active) (CSB-EP017802HU)

驗(yàn)證數(shù)據(jù)

CSB-EP017802HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP017802HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized ABCD1 at 5 μg/ml can bind human PEX19, the EC50 of human PEX19 is 22.96-33.00 μg/ml.

PEX19 Antibody (CSB-PA017802DSR2HU)

驗(yàn)證數(shù)據(jù)

CSB-PA017802DSR2HU

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA017802DSR2HU at dilution of 1:100

CSB-PA017802DSR2HU

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA017802DSR2HU at dilution of 1:100

PEX19 Antibodies

PEX19 for Homo sapiens (Human)

PEX19 Proteins

PEX19 Proteins for Homo sapiens (Human)



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