PABPC1
PABPC1，即多聚腺苷酸結(jié)合蛋白細(xì)胞質(zhì)1型，是細(xì)胞內(nèi)關(guān)鍵的RNA結(jié)合蛋白，也常被稱為PABP1或PABPC。它主要與信使RNA（mRNA）末端的多聚腺苷酸尾巴結(jié)合，既能維持mRNA的結(jié)構(gòu)穩(wěn)定，避免其被過快降解，又能協(xié)助啟動蛋白質(zhì)的合成過程，還參與mRNA在細(xì)胞質(zhì)中的轉(zhuǎn)運與代謝調(diào)節(jié)。
PABPC1的功能異常與多種疾病關(guān)聯(lián)緊密：在乳腺癌、肺癌等惡性腫瘤中，它的表達水平常明顯升高，可能推動腫瘤細(xì)胞的增殖與侵襲；在阿爾茨海默病等神經(jīng)退行性疾病里，它的分布或結(jié)合活性改變，或許與異常蛋白積累、神經(jīng)元功能受損有關(guān)。目前，科研人員正探索調(diào)控PABPC1活性的方法，比如尋找能干擾它與mRNA結(jié)合的小分子化合物，期望為相關(guān)疾病的治療提供新方向。
熱銷產(chǎn)品
Recombinant Human Polyadenylate-binding protein 1 (PABPC1), partial (CSB-EP017352HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PABPC1 Antibody (CSB-PA829516)
驗證數(shù)據(jù)
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: LoVo cells, Hela cells, Primary antibody: CSB-PA829516(PABPC1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds
PABPC1 Antibodies
PABPC1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA017352GA01HU | PABPC1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA829516 | PABPC1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA175056 | PABPC1 Antibody | Human,Mouse,Rat | ELISA,WB |
PABPC1 Proteins
PABPC1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017352HU CSB-BP017352HU CSB-MP017352HU CSB-EP017352HU-B |
Recombinant Human Polyadenylate-binding protein 1 (PABPC1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP017352HU | Recombinant Human Polyadenylate-binding protein 1 (PABPC1), partial | E.coli |
PABPC1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017352MO CSB-EP017352MO CSB-BP017352MO CSB-MP017352MO CSB-EP017352MO-B |
Recombinant Mouse Polyadenylate-binding protein 1 (Pabpc1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PABPC1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017352BO CSB-EP017352BO CSB-BP017352BO CSB-MP017352BO CSB-EP017352BO-B |
Recombinant Bovine Polyadenylate-binding protein 1 (PABPC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PABPC1 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP725331PYX CSB-EP725331PYX CSB-BP725331PYX CSB-MP725331PYX CSB-EP725331PYX-B |
Recombinant Pongo abelii Polyadenylate-binding protein 1 (PABPC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PABPC1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP861666RA CSB-EP861666RA CSB-BP861666RA CSB-MP861666RA CSB-EP861666RA-B |
Recombinant Rat Polyadenylate-binding protein 1 (Pabpc1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
