OGA
OGA，全稱為O-GlcNAcase，是一種負(fù)責(zé)水解O-GlcNAc糖基化蛋白中糖苷鍵的酶。該蛋白在細(xì)胞核和細(xì)胞質(zhì)中廣泛存在，參與調(diào)控蛋白質(zhì)的翻譯后修飾。OGA通過(guò)去除蛋白質(zhì)上的GlcNAc，影響蛋白質(zhì)的結(jié)構(gòu)和功能，進(jìn)而參與多種細(xì)胞生命活動(dòng)。研究表明，OGA蛋白的異常表達(dá)與多種疾病相關(guān)，如阿爾茨海默病、神經(jīng)退行性疾病和癌癥等。針對(duì)OGA蛋白的藥物研發(fā)已成為治療這些疾病的重要方向。研究表明，提高Tau蛋白的O-GlcNAc水平能夠有效降低其磷酸化水平，從而減輕神經(jīng)退行性疾病的癥狀。因此，OGA蛋白的研究對(duì)于開發(fā)新的治療策略具有重要意義。
熱銷產(chǎn)品
MGEA5 Recombinant Monoclonal Antibody (CSB-RA833565A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate, L02 whole cell lysate, HepG2 whole cell lysate
All lanes: MGEA5 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 103, 96, 77, 97 kDa
Observed band size: 130 kDa
OGA Antibodies
OGA for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA013786GA01HU | MGEA5 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA797342 | MGEA5 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA910720 | MGEA5 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-RA833565A0HU | MGEA5 Recombinant Monoclonal Antibody | Human | ELISA, WB |
OGA Proteins
OGA Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP013786HU CSB-EP013786HU CSB-BP013786HU CSB-MP013786HU CSB-EP013786HU-B |
Recombinant Human Protein O-GlcNAcase (MGEA5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
