NTN1
NTN1，即軸突生長誘向因子1，是一種蛋白質(zhì)，由α-螺旋結(jié)構(gòu)組成，并由NTN1基因編碼。這種蛋白質(zhì)在神經(jīng)元的發(fā)育過程中扮演著重要的角色。NTN1通過與其受體識別并結(jié)合，引導神經(jīng)元軸突的生長和突觸的形成。這種結(jié)合通常依賴于Ca2+離子的存在，通過受體激活內(nèi)源性信號傳導通路，最終影響神經(jīng)元的發(fā)育和功能。此外，Netrin-1能夠抑制腫瘤細胞的凋亡（細胞死亡），并促進新血管生成以及控制成纖維細胞。Netrin-1還涉及上皮間質(zhì)轉(zhuǎn)化（EMT）過程。EMT與腫瘤的發(fā)生、進展、轉(zhuǎn)移以及耐藥性緊密相關(guān)。阻斷Netrin-1可以抑制上皮細胞間質(zhì)轉(zhuǎn)化過程，進而對腫瘤的發(fā)展產(chǎn)生重要影響。
熱銷產(chǎn)品
Recombinant Human Netrin-1 (NTN1), partial (Active) (CSB-MP016127HU(A4))
驗證數(shù)據(jù)
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
-AC1.jpg)
Activity
Measured by its binding ability in a functional ELISA.Immobilized Human NTN1 at 2 μg/ml can bind Anti-NTN1 recombinant antibody (CSB-RA016127MA1HU).The EC50 is 26.43-30.77 ng/mL.
NTN1 Antibodies
NTN1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA003404 | NTN1 Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA006035 | NTN1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA016127LA01HU | NTN1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA016127LC01HU | NTN1 Antibody, FITC conjugated | Human | |
| CSB-PA016127LD01HU | NTN1 Antibody, Biotin conjugated | Human | ELISA |
NTN1 Proteins
NTN1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP016127HU CSB-EP016127HU CSB-BP016127HU CSB-MP016127HU CSB-EP016127HU-B |
Recombinant Human Netrin-1 (NTN1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NTN1 ELISA Kit
NTN1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11899h | Human Netrin-1,Ntn1 ELISA Kit | serum, plasma, cell culture supernates | 7.81 pg/mL |
