NPY2R
NPY2R，即神經(jīng)肽Y受體Y2，別名NPY2-R、Y2R。它是一種G蛋白偶聯(lián)受體，屬于神經(jīng)肽Y受體家族成員之一，由人體細胞自身的基因編碼。NPY2R的作用機制主要是通過與神經(jīng)肽Y（NPY）和肽YY（PYY）等配體結(jié)合，激活受體，進而通過Gαi/o蛋白介導的信號通路發(fā)揮生物學效應(yīng)。NPY2R的信號通路涉及抑制腺苷酸環(huán)化酶活性，減少cAMP的生成，進而影響細胞內(nèi)外的信號轉(zhuǎn)導。NPY2R在生物學上的意義非常廣泛，它參與調(diào)節(jié)多種生理功能，包括食欲控制、能量代謝、神經(jīng)傳導等。特別是在調(diào)節(jié)食欲和體重方面，NPY2R發(fā)揮著重要作用，其激動劑能夠減少食物攝入并增加能量消耗，因此NPY2R成為抗肥胖藥物研究的重要靶點。此外，NPY2R的表達和功能異常與多種疾病相關(guān)，如肥胖癥、心血管疾病和某些類型的癌癥。在腫瘤微環(huán)境中，NPY2R的激活可以促進腫瘤細胞的增殖、遷移和侵襲，因此NPY2R也是腫瘤治療中的潛在靶點 。
熱銷產(chǎn)品
Recombinant Human Neuropeptide Y receptor type 2 (NPY2R), partial (CSB-EP016036HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
NPY2R Antibody (CSB-PA016036LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, U87 whole cell lysate, SH-SY5Y whole cell lysate, U251 whole cell lysate, Jurkat whole cell lysate, K562 whole cell lysate
All lanes: NPY2R antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 43 kDa
Observed band size: 43 kDa
Immunofluorescence staining of A549 cells with CSB-PA016036LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
NPY2R Antibodies
NPY2R for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA003472 | NPY2R Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA131945 | NPY2R Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA016036LA01HU | NPY2R Antibody | Human | ELISA, WB, IF |
| CSB-PA016036LB01HU | NPY2R Antibody, HRP conjugated | Human | ELISA |
| CSB-PA016036LC01HU | NPY2R Antibody, FITC conjugated | Human | |
| CSB-PA016036LD01HU | NPY2R Antibody, Biotin conjugated | Human | ELISA |
NPY2R Proteins
NPY2R Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP016036BO1 CSB-EP016036BO1 CSB-BP016036BO1 CSB-MP016036BO1 CSB-EP016036BO1-B |
Recombinant Bovine Neuropeptide Y receptor type 2 (NPY2R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF016036BO | Recombinant Bovine Neuropeptide Y receptor type 2 (NPY2R) | in vitro E.coli expression system |
NPY2R Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP016036SH1 CSB-EP016036SH1 CSB-BP016036SH1 CSB-MP016036SH1 CSB-EP016036SH1-B |
Recombinant Sheep Neuropeptide Y receptor type 2 (NPY2R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF016036SH | Recombinant Sheep Neuropeptide Y receptor type 2 (NPY2R) | in vitro E.coli expression system |
NPY2R Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP016036MO1 CSB-BP016036MO1 CSB-MP016036MO1 CSB-EP016036MO1-B |
Recombinant Mouse Neuropeptide Y receptor type 2 (Npy2r) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF016036MO | Recombinant Mouse Neuropeptide Y receptor type 2 (Npy2r) | in vitro E.coli expression system |
| CSB-EP016036MO1 | Recombinant Mouse Neuropeptide Y receptor type 2 (Npy2r), partial | E.coli |
| CSB-EP016036MO1b0 | Recombinant Mouse Neuropeptide Y receptor type 2 (Npy2r), partial | E.coli |
NPY2R Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP016036HU1 CSB-BP016036HU1 CSB-MP016036HU1 CSB-EP016036HU1-B |
Recombinant Human Neuropeptide Y receptor type 2 (NPY2R), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF016036HU | Recombinant Human Neuropeptide Y receptor type 2 (NPY2R) | in vitro E.coli expression system |
| CSB-EP016036HU1 | Recombinant Human Neuropeptide Y receptor type 2 (NPY2R), partial | E.coli |
| CSB-MP016036HU | Recombinant Human Neuropeptide Y receptor type 2 (NPY2R)-VLPs | Mammalian cell |
NPY2R Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP016036PI1 CSB-EP016036PI1 CSB-BP016036PI1 CSB-MP016036PI1 CSB-EP016036PI1-B |
Recombinant Pig Neuropeptide Y receptor type 2 (NPY2R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF016036PI | Recombinant Pig Neuropeptide Y receptor type 2 (NPY2R) | in vitro E.coli expression system |
NPY2R Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP692216EQV1 CSB-EP692216EQV1 CSB-BP692216EQV1 CSB-MP692216EQV1 CSB-EP692216EQV1-B |
Recombinant Pan troglodytes Neuropeptide Y receptor type 2 (NPY2R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF692216EQV | Recombinant Pan troglodytes Neuropeptide Y receptor type 2 (NPY2R) | in vitro E.coli expression system |
NPY2R Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP875594MOW1 CSB-EP875594MOW1 CSB-BP875594MOW1 CSB-MP875594MOW1 CSB-EP875594MOW1-B |
Recombinant Macaca mulatta Neuropeptide Y receptor type 2 (NPY2R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF875594MOW | Recombinant Macaca mulatta Neuropeptide Y receptor type 2 (NPY2R) | in vitro E.coli expression system |
NPY2R Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP880580CH1 CSB-EP880580CH1 CSB-BP880580CH1 CSB-MP880580CH1 CSB-EP880580CH1-B |
Recombinant Chicken Neuropeptide Y receptor type 2 (NPY2R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF880580CH | Recombinant Chicken Neuropeptide Y receptor type 2 (NPY2R) | in vitro E.coli expression system |
