NOTCH1

NOTCH1，全稱為Notch (Drosophila) homolog 1 (translocation-associated)，是一種參與發(fā)育過程的跨膜糖蛋白，屬于Notch蛋白家族的一員。該蛋白具有多種別名，如TAN1、neurogenic locus notch homolog protein 1等。NOTCH1蛋白在細(xì)胞表面表達(dá)，通過與相鄰細(xì)胞分泌的配體結(jié)合，被切割并釋放其胞內(nèi)結(jié)構(gòu)域，進(jìn)而進(jìn)入細(xì)胞核，參與調(diào)控下游基因的表達(dá)，影響細(xì)胞命運(yùn)決定、增殖、分化等過程。NOTCH1蛋白的異常激活與多種癌癥的發(fā)生發(fā)展密切相關(guān)，如肺癌、結(jié)直腸癌、胃癌及乳腺癌等。針對(duì)NOTCH1蛋白的藥物研發(fā)已取得一定進(jìn)展，例如γ-分泌酶抑制劑（GSI）可通過抑制NOTCH1蛋白的切割來阻斷其信號(hào)通路，已在臨床試驗(yàn)中顯示出一定的抗腫瘤效果。此外，還有針對(duì)NOTCH1受體、配體、γ-分泌酶的單克隆抗體等新型藥物正在研發(fā)中，有望為癌癥治療提供更多選擇。

熱銷產(chǎn)品

Recombinant Human Neurogenic locus notch homolog protein 1 (NOTCH1), partial (CSB-EP015949HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NOTCH1 Recombinant Monoclonal Antibody (CSB-RA599445A0HU)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: HepG2 whole cell lysate, THP-1 whole cell lysate, HL-60 whole cell lysate
All lanes: Notch1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 273 kDa
Observed band size: 120 kDa

IHC image of CSB-RA599445A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Human Neurogenic locus notch homolog protein 1(NOTCH1) ELISA kit (CSB-EL015949HU)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-EL015949HU

規(guī)格：96T/48T

靈敏度：19.5 pg/mL

檢測范圍：78 pg/mL-5000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

NOTCH1 Antibody

NOTCH1 Protein

NOTCH1 ELISA Kit

NOTCH1 Antibodies

NOTCH1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA015949GA01HU	NOTCH1 Antibody	Human,Mouse,Rat,Zebrafish	ELISA,WB,IHC
CSB-PA000057	Cleaved-NOTCH1 (V1754) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA084572	NOTCH1 Antibody	Human,Rat	ELISA,WB,IHC
CSB-PA185075	NOTCH1 Antibody	Human,Rat	ELISA,WB
CSB-PA015949LA01HU	NOTCH1 Antibody	Human	ELISA, IHC, IF
CSB-PA015949LB01HU	NOTCH1 Antibody, HRP conjugated	Human	ELISA
CSB-PA015949LC01HU	NOTCH1 Antibody, FITC conjugated	Human
CSB-PA015949LD01HU	NOTCH1 Antibody, Biotin conjugated	Human	ELISA
CSB-RA599445A0HU	NOTCH1 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC

NOTCH1 Proteins

NOTCH1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP015949HU CSB-BP015949HU CSB-MP015949HU CSB-EP015949HU-B	Recombinant Human Neurogenic locus notch homolog protein 1 (NOTCH1), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP015949HU	Recombinant Human Neurogenic locus notch homolog protein 1 (NOTCH1), partial	E.coli

NOTCH1 Proteins for Xenopus laevis (African clawed frog)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP322025XBE CSB-EP322025XBE CSB-BP322025XBE CSB-MP322025XBE CSB-EP322025XBE-B	Recombinant Xenopus laevis Neurogenic locus notch protein homolog (notch1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli