NEK7
NEK7，全稱為絲氨酸/蘇氨酸蛋白激酶Nek7，是一種在多種組織中表達(dá)的激酶。它屬于NIMA相關(guān)激酶家族，是該家族中最小的一員。NEK7蛋白在細(xì)胞周期調(diào)控中發(fā)揮著重要作用，尤其是在有絲分裂過程中。它通過增強(qiáng)中心體微管成核，確保紡錘體形成，并幫助胞質(zhì)分裂，從而驅(qū)動(dòng)有絲分裂細(xì)胞周期進(jìn)程。此外，NEK7蛋白還能促進(jìn)染色體聚集，并參與NLRP3炎性體組裝和激活，進(jìn)而影響炎癥反應(yīng)。
NEK7蛋白與多種疾病相關(guān)，包括炎癥性疾病和惡性腫瘤。研究表明，NEK7蛋白的異常表達(dá)與多種癌癥的進(jìn)展密切相關(guān)。因此，靶向NEK7蛋白的藥物研發(fā)成為治療相關(guān)疾病的重要方向。目前，已有多種針對(duì)NEK7蛋白的抑制劑被研發(fā)出來，并處于臨床試驗(yàn)階段。這些抑制劑有望成為治療炎癥性疾病和惡性腫瘤的新型藥物。
熱銷產(chǎn)品
Recombinant Human Serine/threonine-protein kinase Nek7 (NEK7) (CSB-EP840576HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
NEK7 Antibody (CSB-PA840576LA01HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescent analysis of Hela cells using CSB-PA840576LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
NEK7 Antibodies
NEK7 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA007295 | NEK7 Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA840576LA01HU | NEK7 Antibody | Human | ELISA, IF |
| CSB-PA840576LB01HU | NEK7 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA840576LC01HU | NEK7 Antibody, FITC conjugated | Human | |
| CSB-PA840576LD01HU | NEK7 Antibody, Biotin conjugated | Human | ELISA |
NEK7 Proteins
NEK7 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015705RA CSB-EP015705RA CSB-BP015705RA CSB-MP015705RA CSB-EP015705RA-B |
Recombinant Rat Serine/threonine-protein kinase Nek7 (Nek7) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NEK7 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP840576HU CSB-BP840576HU CSB-MP840576HU CSB-EP840576HU-B |
Recombinant Human Serine/threonine-protein kinase Nek7 (NEK7) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP840576HU | Recombinant Human Serine/threonine-protein kinase Nek7 (NEK7) | E.coli |
NEK7 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP872141MO CSB-EP872141MO CSB-BP872141MO CSB-MP872141MO CSB-EP872141MO-B |
Recombinant Mouse Serine/threonine-protein kinase Nek7 (Nek7) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NEK7 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP881729DOA CSB-EP881729DOA CSB-BP881729DOA CSB-MP881729DOA CSB-EP881729DOA-B |
Recombinant Arabidopsis thaliana Serine/threonine-protein kinase Nek7 (NEK7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
