NECTIN2
NECTIN2，全稱為Nectin-2，也被稱為CD112、HVEB、PVRL2，是一種參與細(xì)胞連接和信號(hào)傳導(dǎo)的重要蛋白。它作為細(xì)胞粘附分子，在細(xì)胞間相互作用中發(fā)揮關(guān)鍵作用，并與某些病毒（如單純皰疹病毒）的感染相關(guān)。NECTIN2蛋白在免疫細(xì)胞和其他類型細(xì)胞間的相互作用中影響細(xì)胞遷移和組織穩(wěn)態(tài)，同時(shí)也在癌癥和病毒感染等多種疾病中發(fā)揮作用。目前，針對(duì)NECTIN2的藥物研發(fā)主要集中在癌癥治療領(lǐng)域，已有多個(gè)靶向NECTIN2的藥物處于研發(fā)階段。例如，橙帆醫(yī)藥與Avenzo Therapeutics達(dá)成了全球戰(zhàn)略合作協(xié)議，共同研發(fā)和商業(yè)化一種Nectin4-TROP2雙抗ADC藥物，旨在治療晚期實(shí)體瘤。此外，NECTIN2蛋白還與乳腺癌和卵巢癌等疾病相關(guān)，使其成為抗體治療的潛在靶點(diǎn)。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis NECTIN2 at 2 μg/ml can bind Anti-NECTIN2 recombinant antibody(CSB-RA835690MA1HU). The EC50 is 1.011-1.193 ng/mL.
The purity of NECTIN2 was greater than 95% as determined by SEC-HPLC
Recombinant Human Nectin-2 (NECTIN2), partial (CSB-MP835690HUd7)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
NECTIN2 Antibody (CSB-PA835690LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate, Hela whole cell lysate
All lanes: NECTIN2 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 58, 52 kDa
Observed band size: 58 kDa
NECTIN2 Antibodies
NECTIN2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA019096GA01HU | PVRL2 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA006259 | PVRL2 Antibody | Human | WB, ELISA |
| CSB-PA163325 | PVRL2 Antibody | Human | ELISA,IHC |
| CSB-PA835690LA01HU | NECTIN2 Antibody | Human | ELISA, WB |
| CSB-PA835690LB01HU | NECTIN2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA835690LC01HU | NECTIN2 Antibody, FITC conjugated | Human |
NECTIN2 Proteins
NECTIN2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP019096MO1 CSB-EP019096MO1 CSB-BP019096MO1 CSB-MP019096MO1 CSB-EP019096MO1-B |
Recombinant Mouse Poliovirus receptor-related protein 2 (Pvrl2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF019096MO | Recombinant Mouse Nectin-2 (Nectin2) | in vitro E.coli expression system |
NECTIN2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP835690HU CSB-BP835690HU CSB-MP835690HU CSB-EP835690HU-B |
Recombinant Human Poliovirus receptor-related protein 2 (PVRL2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP835690HU | Recombinant Human Nectin-2 (PVRL2), partial | E.coli |
| CSB-AP005081HU | Recombinant Human Nectin-2 (NECTIN2), partial (Active) | Mammalian cell |
