MUC16
MUC16，即粘蛋白16，是一種高度糖基化的跨膜粘蛋白，屬于粘蛋白家族成員之一。它在卵巢上皮性癌細(xì)胞株中被首次發(fā)現(xiàn)，并在多種腫瘤中表達(dá)，特別是在80%以上的卵巢癌中高表達(dá)。MUC16的作用機(jī)制涉及細(xì)胞增殖、遷移、侵襲和轉(zhuǎn)移的調(diào)控，其異常表達(dá)與腫瘤的發(fā)生、增殖和轉(zhuǎn)移密切相關(guān)。MUC16通過(guò)與PI3K/Akt信號(hào)通路的相互作用，增強(qiáng)癌細(xì)胞的增殖、侵襲及轉(zhuǎn)移能力。此外，MUC16還可能與Wnt/β-catenin信號(hào)通路相關(guān)聯(lián)，影響腫瘤的生長(zhǎng)或轉(zhuǎn)移。在生物學(xué)意義上，MUC16不僅在維持上皮細(xì)胞的保護(hù)性屏障功能中發(fā)揮作用，而且其在腫瘤免疫微環(huán)境中的作用也日益受到重視，是腫瘤治療和免疫調(diào)節(jié)中的潛在靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Mucin-16 (MUC16), partial (CSB-MP704410HU3)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MUC16 Antibodies
MUC16 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA10657A0Rb | MUC16/CA125 Antibody | Human | ELISA, IHC |
| CSB-PA10657B0Rb | MUC16/CA125 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA10657C0Rb | MUC16/CA125 Antibody, FITC conjugated | Human | |
| CSB-PA015219GA01HU | MUC16/CA125 Antibody | Human | ELISA,WB |
| CSB-PA899266 | MUC16/CA125 Antibody | Human | ELISA,IF |
| CSB-PA070303 | MUC16/CA125 Antibody | Human | IF, ELISA |
| CSB-PA268943 | MUC16/CA125 Antibody | Human | ELISA,IHC |
| CSB-RA941216A0HU | MUC16/CA125 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
| CSB-RA973154A0HU | MUC16/CA125 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
MUC16 Proteins
MUC16 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-MP704410HU3 | Recombinant Human Mucin-16 (MUC16), partial | Mammalian cell |
| CSB-MP704410HU3c7 | Recombinant Human Mucin-16 (MUC16), partial (Active) | Mammalian cell |
| CSB-EP704410HU3 | Recombinant Human Mucin-16 (MUC16), partial | E.coli |
MUC16 ELISA Kit
MUC16 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04771h | Human Carbonhydrate Antigen 125(CA125) ELISA Kit | serum, plasma | 3.8 U/ml. |
