MT1A

金屬硫蛋白1A（Metallothionein 1A，簡稱MT1A）是一類廣泛存在于人體組織的小分子蛋白，因其富含半胱氨酸殘基也被稱作"金屬結(jié)合衛(wèi)士"。MT1A通過螯合鋅、銅等必需金屬離子，維持細(xì)胞內(nèi)環(huán)境穩(wěn)定，同時能高效中和重金屬毒性物質(zhì)如鎘和汞，在肝臟解毒過程中發(fā)揮核心作用。其抗氧化特性對抵御自由基損傷、延緩細(xì)胞衰老具有重要價值。
MT1A表達(dá)異常與多種病理狀態(tài)相關(guān)。在阿爾茨海默病、帕金森病等神經(jīng)退行性疾病中，患者腦部MT1A水平顯著下降，提示其可能參與神經(jīng)保護(hù)過程。肝癌、乳腺癌等惡性腫瘤組織常出現(xiàn)該蛋白的異常高表達(dá)，可能與腫瘤細(xì)胞抵抗化療藥物及適應(yīng)缺氧微環(huán)境有關(guān)。近年針對MT1A的調(diào)控策略逐漸受到關(guān)注，包括利用其作為重金屬中毒的生物標(biāo)志物，開發(fā)基于金屬硫蛋白結(jié)構(gòu)的仿生解毒劑，以及探索通過表觀遺傳手段調(diào)節(jié)其表達(dá)來增強(qiáng)抗癌療效。天然產(chǎn)物如姜黃素已被證實可誘導(dǎo)MT1A生成，為抗氧化治療提供了新思路。

熱銷產(chǎn)品

Recombinant Human Metallothionein-1A (MT1A), partial (CSB-EP015107HU1)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

MT1A Antibody (CSB-PA17444A0Rb)

驗證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA17444A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA17444A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA17444A0Rb at dilution of 1:100

Human Metallothionein,MT ELISA Kit (CSB-E09060h)

驗證數(shù)據(jù)

貨號：CSB-E09060h

規(guī)格：96T/48T

靈敏度：0.813 pg/mL

檢測范圍：6.25 pg/mL-400 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

MT1A Antibody

MT1A Protein

MT1A ELISA Kit

MT1A Antibodies

MT1A for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA17444C0Rb	MT1A Antibody, FITC conjugated	Human
CSB-PA17444A0Rb	MT1A Antibody	Human	ELISA, IHC

MT1A Proteins

MT1A Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015107HU CSB-EP015107HU CSB-BP015107HU CSB-MP015107HU CSB-EP015107HU-B	Recombinant Human Metallothionein-1A (MT1A)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP015107HU1	Recombinant Human Metallothionein-1A (MT1A), partial	E.coli