MSLN

MSLN，即間皮素（Mesothelin），是一種糖基磷脂酰肌醇(GPI)錨定的細(xì)胞表面糖蛋白，由MSLN基因編碼的前蛋白經(jīng)過蛋白水解后產(chǎn)生巨核細(xì)胞增強因子和間皮素兩種蛋白產(chǎn)物。
MSLN的作用機(jī)制涉及其在細(xì)胞表面的表達(dá)，通過與配體如CA125/MUC16的高親和力相互作用促進(jìn)異型細(xì)胞粘附，進(jìn)而影響腫瘤的轉(zhuǎn)移。此外，MSLN的過表達(dá)能夠激活NF-κB、MAPK和PI3K-激酶促進(jìn)細(xì)胞增殖和抵抗凋亡的細(xì)胞內(nèi)通路。MSLN在正常組織中的表達(dá)有限，但在卵巢癌、乳腺癌、結(jié)直腸癌和胰腺癌等幾種實體腫瘤中的過度表達(dá)，與較低的存活率相關(guān)，是腫瘤特異性治療的理想靶點。

熱銷產(chǎn)品

Recombinant Human Mesothelin (MSLN), partial (Active) (CSB-MP015044HUc9)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized MSLN at 2 μg/ml can bind Anti-MSLN rabbit monoclonal antibody, the EC₅₀ of the MSLN protein is 2.657-3.177 ng/ml.

Activity
Measured by its binding ability in a functional ELISA. Immobilized MUC16(CSB-MP704410HU3c7) at 10 μg/ml can bind MSLN, the EC₅₀ is 460.7-662.2 ng/ml.

MSLN Antibody (CSB-PA015044ESR1HU)

驗證數(shù)據(jù)

Western blot
All lanes: MSLN antibody at 8µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 69, 72, 68 kDa
Observed band size: 69 kDa

Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA015044ESR1HU at dilution of 1:100

MSLN Antibody

MSLN Protein

MSLN ELISA Kit

MSLN Antibodies

MSLN for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA015044LA01MO	Msln Antibody	Mouse	ELISA
CSB-PA015044LB01MO	Msln Antibody, HRP conjugated	Mouse	ELISA
CSB-PA015044LC01MO	Msln Antibody, FITC conjugated	Mouse
CSB-PA015044LD01MO	Msln Antibody, Biotin conjugated	Mouse	ELISA

MSLN for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA10159A0Rb	MSLN Antibody	Human	ELISA, IHC, IF, IP
CSB-PA10159B0Rb	MSLN Antibody, HRP conjugated	Human	ELISA
CSB-PA10159C0Rb	MSLN Antibody, FITC conjugated	Human
CSB-PA10159D0Rb	MSLN Antibody, Biotin conjugated	Human	ELISA
CSB-PA015044ESR1HU	MSLN Antibody	Human	ELISA, WB, IHC
CSB-PA015044ESR2HU	MSLN Antibody	Human	ELISA, IHC
CSB-PA846777	MSLN Antibody	Human	ELISA,IHC
CSB-PA952111	MSLN Antibody	Human	ELISA,IHC

MSLN Proteins

MSLN Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015044MO	Recombinant Mouse Mesothelin (Msln), partial	Yeast
CSB-EP015044MO	Recombinant Mouse Mesothelin (Msln), partial	E.coli
CSB-BP015044MO CSB-MP015044MO CSB-EP015044MO-B	Recombinant Mouse Mesothelin (Msln), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSLN Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015044RA CSB-EP015044RA CSB-BP015044RA CSB-MP015044RA CSB-EP015044RA-B	Recombinant Rat Mesothelin (Msln)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSLN Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-MP015044HU	Recombinant Human Mesothelin (MSLN), partial	Mammalian cell
CSB-MP015044HUf3	Recombinant Human Mesothelin (MSLN), partial	Mammalian cell
CSB-MP015044HUc9	Recombinant Human Mesothelin (MSLN), partial (Active)	Mammalian cell
CSB-MP015044HU-B	Recombinant Human Mesothelin (MSLN), partial,Biotinylated	Mammalian cell