MKRN2
MKRN2，全稱(chēng)為 makorin 無(wú)名指蛋白 2，是一種在人體多種組織中表達(dá)的蛋白質(zhì)。它也被稱(chēng)為 RING 指蛋白 62 或 HSPC070。MKRN2 蛋白參與多種生理過(guò)程，包括細(xì)胞周期調(diào)控、細(xì)胞凋亡和睪丸發(fā)育。近年來(lái)，研究發(fā)現(xiàn) MKRN2 蛋白在炎癥調(diào)控中發(fā)揮著重要作用。它可以通過(guò)與促炎細(xì)胞因子白介素-6（IL-6）的信使RNA結(jié)合，抑制 IL-6 的翻譯效率，從而減輕炎癥反應(yīng)。這一發(fā)現(xiàn)為治療自身免疫性疾病提供了新的思路。目前，一些針對(duì) MKRN2 蛋白的藥物正在研發(fā)中，有望為炎癥性疾病患者帶來(lái)新的治療選擇。
熱銷(xiāo)產(chǎn)品
MKRN2 Antibody (CSB-PA872420LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Rat kidney tissue, Rat liver tissue, Mouse kidney tissue
All lanes: MKRN2 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 47, 42 kDa
Observed band size: 47 kDa
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA872420LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA872420LA01HU at dilution of 1:100
MKRN2 Antibodies
MKRN2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA014606GA01HU | MKRN2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA872420LA01HU | MKRN2 Antibody | Human, Mouse, Rat | ELISA, WB, IHC |
| CSB-PA872420LB01HU | MKRN2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA872420LD01HU | MKRN2 Antibody, Biotin conjugated | Human | ELISA |
MKRN2 Proteins
MKRN2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP872420HU CSB-EP872420HU CSB-BP872420HU CSB-MP872420HU CSB-EP872420HU-B |
Recombinant Human Probable E3 ubiquitin-protein ligase makorin-2 (MKRN2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
