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METAP2

METAP2,即甲硫氨酰氨肽酶2,別名MAP2、MNPEP、p67、Peptidase M等。它是一種在所有生物體中存在的酶,具有關(guān)鍵的組織修復(fù)和蛋白質(zhì)降解功能。METAP2的作用機(jī)制主要是在蛋白質(zhì)合成過程中,共翻譯地移除新生多肽鏈上的N-末端甲硫氨酸,這一過程對(duì)于蛋白質(zhì)的成熟和功能發(fā)揮至關(guān)重要。特別是,當(dāng)多肽鏈的第二個(gè)殘基是小的非極性氨基酸時(shí),如丙氨酸、半胱氨酸、甘氨酸、脯氨酸、絲氨酸、蘇氨酸或纈氨酸,METAP2的催化活性會(huì)顯著提高 。METAP2在生物學(xué)上的意義非常廣泛,它不僅參與了蛋白質(zhì)合成的調(diào)控,還與多種生物學(xué)過程相關(guān),包括血管生成、細(xì)胞增殖和腫瘤發(fā)展等。由于在血管生成中的關(guān)鍵作用,METAP2成為了治療某些疾病如實(shí)體瘤癌癥和類風(fēng)濕性關(guān)節(jié)炎的潛在靶點(diǎn)。此外,METAP2的抑制劑,例如Fumagillin和Ovalicin,已被研究用于抗癌藥物的開發(fā),并且有研究顯示,針對(duì)METAP2的抑制劑還能夠有效治療肥胖癥 。

熱銷產(chǎn)品

Recombinant Human Methionine aminopeptidase 2 (METAP2) (CSB-EP013716HU)

驗(yàn)證數(shù)據(jù)

CSB-EP013716HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP013716HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP013716HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) METAP2.

CSB-EP013716HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP013716HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) METAP2.

METAP2 Recombinant Monoclonal Antibody (CSB-RA294332A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA294332A0HU

IHC image of CSB-RA294332A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

METAP2 Antibodies

METAP2 for Homo sapiens (Human)

METAP2 Proteins

METAP2 Proteins for Homo sapiens (Human)



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