MAP2K2

MAP2K2，即絲裂原活化蛋白激酶激酶2，別名MEK2、MKK2等。它是一種雙特異性蛋白激酶，屬于MAP激酶激酶家族成員，由人體細(xì)胞自身的基因編碼。MAP2K2在細(xì)胞的增殖、分化、細(xì)胞粘附和轉(zhuǎn)錄等多種生物學(xué)過程中發(fā)揮著重要作用。其作用機(jī)制主要是通過接受上游RAF激酶的磷酸化激活信號，進(jìn)而對下游的ERK1/2（胞外信號調(diào)節(jié)激酶1/2）進(jìn)行磷酸化，從而激活ERK1/2作為轉(zhuǎn)錄調(diào)節(jié)因子。MAP2K2在生物學(xué)上的意義非常重大，它參與調(diào)控的信號通路是細(xì)胞增殖、應(yīng)激、炎癥、分化、功能同步化、轉(zhuǎn)化、凋亡等信號轉(zhuǎn)導(dǎo)通路的共同交匯通路之一。MAP2K2的活性對于細(xì)胞對多種生長因子、細(xì)胞因子、射線、滲透壓等刺激的響應(yīng)至關(guān)重要。此外，MAP2K2的異常激活與多種癌癥的發(fā)生發(fā)展有關(guān)，其抑制或降解也參與了某些病原體如耶爾森菌和炭疽的致病機(jī)制。

熱銷產(chǎn)品

MAP2K2 Antibody (CSB-PA04909A0Rb)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: HL60 whole cell lysate
All lanes: MAP2K2 antibody at 2.8µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45 kDa
Observed band size: 45 kDa

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA04909A0Rb at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA04909A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

MAP2K2 Antibody

MAP2K2 Protein

MAP2K2 Antibodies

MAP2K2 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA013411GA01HU	MAP2K2 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA062510	Phospho-MAP2K2 (Thr394) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA898246	MAP2K2 (Ab-394) Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA000570	Phospho-MAP2K2 (T394) Antibody	Human,Mouse,Rat	WB, IHC, IP, ELISA
CSB-PA030302	MAP2K2 Antibody	Human,Mouse,Rat	WB, IHC, IP, ELISA
CSB-PA080229	MAP2K2 Antibody	Human,Mouse,Rat	WB, IHC
CSB-PA097880	MAP2K2 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA224661	MAP2K2 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA04909A0Rb	MAP2K2 Antibody	Human	ELISA, WB, IHC, IF
CSB-PA04909C0Rb	MAP2K2 Antibody, FITC conjugated	Human
CSB-PA04909D0Rb	MAP2K2 Antibody, Biotin conjugated	Human	ELISA
CSB-PA101222	MAP2K2 Antibody	Human	WB, IHC, ELISA
CSB-MA671424	MAP2K2 Monoclonal Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF,IP

MAP2K2 Proteins

MAP2K2 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP013411HU CSB-EP013411HU CSB-BP013411HU CSB-MP013411HU CSB-EP013411HU-B	Recombinant Human Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MAP2K2 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP013411RA CSB-EP013411RA CSB-BP013411RA CSB-MP013411RA CSB-EP013411RA-B	Recombinant Rat Dual specificity mitogen-activated protein kinase kinase 2 (Map2k2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MAP2K2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP626627DO CSB-EP626627DO CSB-BP626627DO CSB-MP626627DO CSB-EP626627DO-B	Recombinant Dog Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MAP2K2 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP723614MO CSB-EP723614MO CSB-BP723614MO CSB-MP723614MO CSB-EP723614MO-B	Recombinant Mouse Dual specificity mitogen-activated protein kinase kinase 2 (Map2k2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MAP2K2 Proteins for Cyprinus carpio (Common carp)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP835446EQE CSB-EP835446EQE CSB-BP835446EQE CSB-MP835446EQE CSB-EP835446EQE-B	Recombinant Cyprinus carpio Dual specificity mitogen-activated protein kinase kinase 2 (map2k2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MAP2K2 Proteins for Gallus gallus (Chicken)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP838569CH CSB-EP838569CH CSB-BP838569CH CSB-MP838569CH CSB-EP838569CH-B	Recombinant Chicken Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli