MAP1LC3B
MAP1LC3B，全稱為微管相關(guān)蛋白1輕鏈3β，常用別名是LC3B。它是細(xì)胞內(nèi)一種關(guān)鍵的功能蛋白，在細(xì)胞應(yīng)對(duì)營養(yǎng)缺乏、損傷刺激等情況時(shí)扮演重要角色：當(dāng)細(xì)胞處于壓力狀態(tài)下，LC3B會(huì)發(fā)生特定化學(xué)修飾，參與形成包裹性的小結(jié)構(gòu)，將細(xì)胞內(nèi)受損的蛋白質(zhì)、老化細(xì)胞器等“廢物”包裹起來，再運(yùn)送到降解結(jié)構(gòu)中處理，幫助細(xì)胞回收資源、維持正常運(yùn)作。
LC3B的功能異常與多種疾病關(guān)聯(lián)緊密。在肺癌、乳腺癌等腫瘤中，它的表達(dá)或修飾狀態(tài)常出現(xiàn)異常，部分腫瘤細(xì)胞會(huì)借助LC3B相關(guān)的過程獲取生存優(yōu)勢(shì)；而阿爾茨海默病等神經(jīng)疾病里，LC3B參與的細(xì)胞清理功能下降，可能導(dǎo)致異常蛋白堆積，加重病情。目前相關(guān)藥物研發(fā)也在推進(jìn)，一些小分子化合物試圖通過調(diào)節(jié)LC3B的活性來影響細(xì)胞清理過程，有望成為癌癥或神經(jīng)疾病的治療新方向，不過多數(shù)仍處于實(shí)驗(yàn)室研究或早期臨床階段。
熱銷產(chǎn)品
Recombinant Human Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) (CSB-EP887936HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MAP1LC3B Recombinant Monoclonal Antibody (CSB-RA577287A0HU)
驗(yàn)證數(shù)據(jù)
Flow cytometric analysis of LC3B expression in H9c2 cells using LC3B antibody. Green, isotype control; red, LC3B.
Western blotting analysis using LC3B antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with LC3B antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
Immunocytochemical staining of H9C2 cells with LC3B antibody. Nuclei were stained blue with DAPI; LC3B was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain：Medium. Scale bar, 20 μm.
MAP1LC3B Antibody (CSB-PA887936LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA887936LA01HU at dilution of 1:100
Human Microtubule-associated proteins 1A/1B light chain 3B(MAP1LC3B) ELISA kit (CSB-EL013403HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL013403HU
規(guī)格：96T/48T
靈敏度：4.67 pg/mL
檢測(cè)范圍：18.75 pg/mL-1200 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
MAP1LC3B Antibodies
MAP1LC3B for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA013403GA01HU | MAP1LC3B Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA080175 | MAP1LC3B Antibody | Human,Mouse,Rat | WB, IHC |
| CSB-PA801588 | MAP1LC3B Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-MA171423 | MAP1LC3B Monoclonal Antibody | Human | ELISA,IHC |
| CSB-PA887936LA01HU | MAP1LC3B Antibody | Human | ELISA, IHC |
| CSB-PA887936LB01HU | MAP1LC3B Antibody, HRP conjugated | Human | ELISA |
| CSB-PA887936LC01HU | MAP1LC3B Antibody, FITC conjugated | Human | |
| CSB-PA887936LD01HU | MAP1LC3B Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA551427A0HU | MAP1LC3B Recombinant Monoclonal Antibody | Human | ELISA, WB, FC |
| CSB-RA577287A0HU | MAP1LC3B Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC, ICC |
MAP1LC3B Proteins
MAP1LC3B Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP887936HU CSB-MP887936HU CSB-EP887936HU-B |
Recombinant Human Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP887936HU | Recombinant Human Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) | E.coli |
| CSB-YP887936HU | Recombinant Human Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) | Yeast |
MAP1LC3B ELISA Kit
MAP1LC3B ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL013403HU | Human Microtubule-associated proteins 1A/1B light chain 3B(MAP1LC3B) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 4.67 pg/mL |
