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LSR

LSR,全稱為緊密連接蛋白LSR(Lens-shaped protein-related),是一種參與細(xì)胞緊密連接形成的蛋白質(zhì)。該蛋白常見別名包括Lsrin、TJP2等。LSR蛋白在細(xì)胞中主要通過(guò)與其他緊密連接蛋白相互作用,參與維持細(xì)胞膜的完整性和選擇性通透性,對(duì)腸道屏障功能尤為重要。研究發(fā)現(xiàn),LSR蛋白能夠與新冠病毒受體ACE2結(jié)合,阻止病毒刺突蛋白與其結(jié)合,從而抑制病毒入侵細(xì)胞。此外,LSR蛋白的缺失會(huì)增強(qiáng)ACE2依賴性SARS-CoV-2病毒的感染,而外源性補(bǔ)充LSR蛋白則能有效保護(hù)宿主免受病毒感染。這一發(fā)現(xiàn)為開發(fā)抗新冠病毒藥物提供了新的靶點(diǎn)。目前,基于LSR蛋白的短肽已被證實(shí)能在體外阻斷S蛋白與ACE2受體的結(jié)合,展現(xiàn)出治療和干預(yù)冠狀病毒變異株的潛力。此外,LSR蛋白的異常表達(dá)與某些癌癥的發(fā)生發(fā)展密切相關(guān),因此也成為癌癥免疫治療的重要靶點(diǎn)。針對(duì)LSR蛋白的抗體藥物和衍生短肽等正在研發(fā)中,有望為相關(guān)疾病的治療提供新的選擇。

熱銷產(chǎn)品

Recombinant Human Lipolysis-stimulated lipoprotein receptor (LSR), partial (CSB-EP801252HU)

驗(yàn)證數(shù)據(jù)

CSB-EP801252HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP801252HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP801252HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) LSR.

CSB-EP801252HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP801252HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) LSR.

LSR Antibody (CSB-PA801252LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA801252LA01HU

IHC image of CSB-PA801252LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA801252LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA801252LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human Lipolysis-stimulated lipoprotein receptor(LSR) ELISA kit (CSB-EL013215HU)

驗(yàn)證數(shù)據(jù)

CSB-EL013215HU 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-EL013215HU

規(guī)格:96T/48T

靈敏度:1.56 pg/mL

檢測(cè)范圍:6.25 pg/mL-400 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

LSR Antibodies

LSR for Homo sapiens (Human)

LSR Proteins

LSR Proteins for Homo sapiens (Human)

LSR ELISA Kit

LSR ELISA Kit for Homo sapiens (Human)



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