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LGMN

LGMN,全稱為LGMN(Lysyl-tRNA synthetase interacting protein 1),是一種參與蛋白質(zhì)合成的重要調(diào)控蛋白。該蛋白也被稱為LysRS-interacting protein 1,主要在細(xì)胞核內(nèi)發(fā)揮作用,通過與其他蛋白的相互作用影響翻譯過程。LGMN蛋白在多種細(xì)胞活動(dòng)中扮演關(guān)鍵角色,包括細(xì)胞增殖、分化和凋亡。研究表明,LGMN蛋白的表達(dá)水平與多種疾病密切相關(guān),尤其是癌癥和自身免疫性疾病。在癌癥中,LGMN蛋白的異常表達(dá)可能促進(jìn)腫瘤生長和轉(zhuǎn)移;而在自身免疫性疾病中,LGMN蛋白的失調(diào)則可能加劇炎癥反應(yīng)。
近年來,針對LGMN蛋白的藥物研發(fā)取得了一定進(jìn)展。由于其在疾病發(fā)生發(fā)展中的重要作用,LGMN蛋白成為藥物設(shè)計(jì)的潛在靶點(diǎn)。目前,已有多種靶向LGMN蛋白的小分子抑制劑進(jìn)入臨床試驗(yàn)階段,旨在通過抑制其功能來治療癌癥和自身免疫性疾病。例如,某款正在研發(fā)的靶向LGMN蛋白的抗體藥物,在早期臨床試驗(yàn)中顯示出良好的抗腫瘤活性,為患者提供了新的治療選擇。隨著研究的深入,LGMN蛋白有望成為未來藥物研發(fā)的重要方向。

熱銷產(chǎn)品

Recombinant Macaca fascicularis Legumain (LGMN) (Active) (CSB-MP012903MOV1)

驗(yàn)證數(shù)據(jù)

CSB-MP012903MOV1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP012903MOV1

Activity
Measured by its ability to cleave the fluorogenic peptide substrate, N-carbobenzyloxy-Ala-Ala-Asn-7-amido-4-methylcoumarin (Z-AAN-AMC). The specific activity is >500 pmol/min/μg.

Recombinant Human Legumain (LGMN) (Active) (CSB-MP012903HU(A4))

驗(yàn)證數(shù)據(jù)

CSB-MP012903HU(A4)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP012903HU(A4)

Activity
Measured by its ability to cleave the fluorogenic peptide substrate, N-carbobenzyloxy-Ala-Ala-Asn-7-amido-4-methylcoumarin (Z-AAN-AMC). The specific activity is >400 pmol/min/μg.

Recombinant Mouse Legumain (Lgmn) (Active) (CSB-MP012903MO1)

驗(yàn)證數(shù)據(jù)

CSB-MP012903MO1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP012903MO1

Activity
Measured by its ability to cleave the fluorogenic peptide substrate, N-carbobenzyloxy-Ala-Ala-Asn-7-amido-4-methylcoumarin (Z-AAN-AMC). The specific activity is >400 pmol/min/μg.

Recombinant Human Legumain (LGMN) (CSB-EP012903HU)

驗(yàn)證數(shù)據(jù)

CSB-EP012903HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LGMN Antibody (CSB-PA012903LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA012903LA01HU

IHC image of CSB-PA012903LA01HU diluted at 1:600 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA012903LA01HU

IHC image of CSB-PA012903LA01HU diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human Legumain(LGMN) ELISA kit (CSB-EL012903HU)

驗(yàn)證數(shù)據(jù)

CSB-EL012903HU 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-EL012903HU

規(guī)格:96T/48T

靈敏度:15.6 pg/mL

檢測范圍:62.5 pg/mL-4000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

LGMN Antibodies

LGMN for Homo sapiens (Human)

LGMN Proteins

LGMN Proteins for Mus musculus (Mouse)

LGMN Proteins for Pongo abelii (Sumatran orangutan)

LGMN Proteins for Bos taurus (Bovine)

LGMN Proteins for Homo sapiens (Human)

LGMN Proteins for Rattus norvegicus (Rat)

LGMN Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

LGMN ELISA Kit

LGMN ELISA Kit for Homo sapiens (Human)



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