KIDINS220
KIDINS220，全名為kinase D-interacting substrate 220，常見(jiàn)別稱(chēng)為ankyrin repeat-rich membrane-spanning protein（ARMS）。該蛋白主要在神經(jīng)系統(tǒng)中表達(dá)，參與神經(jīng)元細(xì)胞的存活、分化和突觸可塑性調(diào)控。KIDINS220與膜受體及細(xì)胞溶質(zhì)蛋白相互作用，影響神經(jīng)元功能。研究表明，KIDINS220在神經(jīng)退行性疾病如阿爾茨海默病和帕金森病中發(fā)揮重要作用，其異常表達(dá)可能與疾病進(jìn)展相關(guān)。此外，KIDINS220還與癌癥發(fā)生有關(guān)，特別是卵巢癌和子宮癌，抑制其磷酸鹽輸出可能成為治療癌癥的新策略。目前，針對(duì)KIDINS220的藥物研發(fā)正在積極探索，例如通過(guò)調(diào)節(jié)XPR1:KIDINS220蛋白復(fù)合物的磷酸化狀態(tài)來(lái)治療癌癥。相關(guān)研究為開(kāi)發(fā)針對(duì)神經(jīng)退行性疾病和癌癥的藥物提供了新的靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
KIDINS220 Antibody (CSB-PA012306LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate
All lanes: KIDINS220 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 197, 186, 116, 195, 60 kDa
Observed band size: 197 kDa
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA012306LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA012306LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA012306LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
KIDINS220 Antibodies
KIDINS220 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA012306GA01HU | KIDINS220 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA928650 | KIDINS220 Antibody | Human,Rat | ELISA,WB |
| CSB-PA012306LA01HU | KIDINS220 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA012306LB01HU | KIDINS220 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012306LC01HU | KIDINS220 Antibody, FITC conjugated | Human |
KIDINS220 Proteins
KIDINS220 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP872116RA CSB-EP872116RA CSB-BP872116RA CSB-MP872116RA CSB-EP872116RA-B |
Recombinant Rat Kinase D-interacting substrate of 220 kDa (Kidins220), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KIDINS220 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP890930HU CSB-EP890930HU CSB-BP890930HU CSB-MP890930HU CSB-EP890930HU-B |
Recombinant Human Kinase D-interacting substrate of 220 kDa (KIDINS220), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
