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KAT2A

KAT2A,即賴(lài)氨酸乙酰轉(zhuǎn)移酶2A,別名GCN5、hGCN5、GCN5L2、PCAF-b等。這是一種在人類(lèi)細(xì)胞中廣泛表達(dá)的組蛋白乙酰轉(zhuǎn)移酶(HAT),主要作用是作為轉(zhuǎn)錄激活劑,通過(guò)乙?;M蛋白促進(jìn)基因的轉(zhuǎn)錄激活。KAT2A還具有其他功能,例如通過(guò)促進(jìn)NF-kappa-B亞基RELA的泛素化來(lái)充當(dāng)NF-kappa-B的阻遏物。此外,KAT2A還參與了多種生物學(xué)過(guò)程,包括長(zhǎng)期記憶、大分子代謝過(guò)程的正向調(diào)控、調(diào)節(jié)性T細(xì)胞分化等。KAT2A的異常表達(dá)與多種疾病相關(guān),如癌癥、代謝性疾病等,是藥物開(kāi)發(fā)的重要靶點(diǎn)之一。

熱銷(xiāo)產(chǎn)品

KAT2A Antibody (CSB-PA002657)

驗(yàn)證數(shù)據(jù)

CSB-PA002657

IHC image of CSB-PA002657 diluted at 1:66 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-PA002657

IHC image of CSB-PA002657 diluted at 1:66 and staining in paraffin-embedded human melanoma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-PA002657

Immunofluorescence staining of Hela cell with CSB-PA002657 at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

KAT2A Antibodies

KAT2A for Homo sapiens (Human)

KAT2A Proteins

KAT2A Proteins for Homo sapiens (Human)

KAT2A Proteins for Mus musculus (Mouse)



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