ITGB8
ITGB8，全稱為整合素β8（Integrin subunit beta 8），是一種參與細(xì)胞外基質(zhì)相互作用的蛋白質(zhì)，常見(jiàn)別名為CD299。該蛋白與α亞基結(jié)合形成異二聚體整合素，在細(xì)胞粘附、遷移和信號(hào)傳導(dǎo)中發(fā)揮關(guān)鍵作用。ITGB8蛋白主要參與免疫應(yīng)答和炎癥反應(yīng)，通過(guò)調(diào)節(jié)細(xì)胞因子和生長(zhǎng)因子的表達(dá)影響免疫細(xì)胞的功能。此外，ITGB8蛋白還與腫瘤的發(fā)生發(fā)展密切相關(guān)，其在結(jié)直腸癌等惡性腫瘤中的高表達(dá)與腫瘤的侵襲和轉(zhuǎn)移密切相關(guān)。針對(duì)ITGB8蛋白的藥物研發(fā)已取得一定進(jìn)展，例如通過(guò)抑制ITGB8蛋白的表達(dá)或活性，可以有效抑制腫瘤細(xì)胞的生長(zhǎng)和轉(zhuǎn)移。目前，一些靶向ITGB8蛋白的小分子化合物和抗體藥物正在臨床研究中，有望成為治療腫瘤等疾病的新型藥物。
熱銷產(chǎn)品
ITGB8 Antibody (CSB-PA011892ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: ITGB8 antibody at 1.52µg/ml
Lane 1: 293T whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: HepG2 whole cell lysate
Lane 4: A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 86, 72 kDa
Observed band size: 86 kDa
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA011892ESR1HU at dilution of 1:100
ITGB8 Antibodies
ITGB8 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011892ESR1HU | ITGB8 Antibody | Human | ELISA, WB, IHC |
ITGB8 Proteins
ITGB8 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011892RB | Recombinant Rabbit Integrin beta-8 (ITGB8), partial | Yeast |
| CSB-CF011892RB | Recombinant Rabbit Integrin beta-8 (ITGB8) | in vitro E.coli expression system |
| CSB-EP011892RB | Recombinant Rabbit Integrin beta-8 (ITGB8), partial | E.coli |
| CSB-BP011892RB CSB-MP011892RB CSB-EP011892RB-B |
Recombinant Rabbit Integrin beta-8 (ITGB8), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB8 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011892HU1 CSB-EP011892HU1 CSB-BP011892HU1 CSB-MP011892HU1 CSB-EP011892HU1-B |
Recombinant Human Integrin beta-8 (ITGB8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011892HU | Recombinant Human Integrin beta-8 (ITGB8) | in vitro E.coli expression system |
ITGB8 ELISA Kit
ITGB8 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011892HU | Human Integrin beta-8(ITGB8) ELISA kit | serum, plasma,tissue homogenates | 0.09 ng/mL |
