ITAM
ITAM蛋白，全稱為免疫受體酪氨酸激活基序（Immunoreceptor tyrosine-based activation motif），是一種磷酸化基序，常見別名包括免疫受體酪氨酸激活基序。ITAM蛋白主要參與免疫細胞的信號傳導，其酪氨酸殘基被磷酸化后，能夠招募胞內(nèi)蛋白激酶或銜接蛋白，從而傳遞活化信號，促進細胞活化。ITAM蛋白廣泛存在于免疫受體中，如T細胞受體復合物、B細胞受體復合物以及某些Fc受體，參與免疫細胞的發(fā)育、分化和功能調(diào)節(jié)。
ITAM蛋白與多種疾病相關，如免疫缺陷病、自身免疫病、腫瘤等。例如，ITAM蛋白的突變或功能異?？赡軐е耇細胞或B細胞的功能缺陷，進而引發(fā)免疫缺陷病。此外，ITAM蛋白還與腫瘤的發(fā)生發(fā)展密切相關，其異常表達或功能可能導致腫瘤細胞的增殖、轉(zhuǎn)移和耐藥性。
目前，針對ITAM蛋白的藥物研發(fā)主要集中在免疫調(diào)節(jié)方面。例如，研究人員正在開發(fā)能夠抑制ITAM蛋白磷酸化的藥物，以抑制免疫細胞的活化，從而治療自身免疫病和腫瘤等疾病。此外，研究人員還在開發(fā)能夠特異性地靶向ITAM蛋白的抗體藥物，以治療免疫缺陷病和腫瘤等疾病。
熱銷產(chǎn)品
Recombinant Human Integrin alpha-M (ITGAM), partial (CSB-EP011876HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ITGAM Antibody (CSB-PA011876LA01HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA011876LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA011876LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA011876LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Integrin αM,ITG/CD11b ELISA Kit (CSB-E11638h)
驗證數(shù)據(jù)
貨號：CSB-E11638h
規(guī)格：96T/48T
靈敏度：0.195 ng/mL
檢測范圍：0.78 ng/mL-50 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ITAM Antibodies
ITAM for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA148981 | ITGAM Antibody | Human | ELISA,IHC |
| CSB-PA073350 | ITGAM Antibody | Human | ELISA,IHC |
| CSB-PA011876LA01HU | ITGAM Antibody | Human | ELISA, IHC, IF |
| CSB-PA011876LB01HU | ITGAM Antibody, HRP conjugated | Human | ELISA |
| CSB-PA011876LC01HU | ITGAM Antibody, FITC conjugated | Human | |
| CSB-PA011876LD01HU | ITGAM Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA067983A0HU | ITGAM Recombinant Monoclonal Antibody | Human | ELISA, WB |
ITAM Proteins
ITAM Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP011876HU CSB-MP011876HU CSB-EP011876HU-B |
Recombinant Human Integrin alpha-M (ITGAM), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP011876HU | Recombinant Human Integrin alpha-M (ITGAM), partial | E.coli |
| CSB-EP011876HUc7 | Recombinant Human Integrin alpha-M (ITGAM), partial | E.coli |
ITAM ELISA Kit
ITAM ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11638h | Human Integrin αM,ITG/CD11b ELISA Kit | serum, plasma, tissue homogenates | 0.195 ng/mL |
