IL13RA2
IL13RA2，即白細(xì)胞介素13受體α2鏈。別名CD213a2。它主要在多種腫瘤細(xì)胞中表達(dá)，包括黑色素瘤、腎細(xì)胞癌、腎上腺皮質(zhì)癌等。IL13RA2的作用機(jī)制復(fù)雜，最初被認(rèn)為是誘餌受體，能封閉IL-13，抑制信號(hào)傳導(dǎo)。但最新研究表明，IL13Rα2在癌細(xì)胞中可以介導(dǎo)IL-13信號(hào)，通過不依賴STAT6的途徑，涉及AP-1和ERK，促進(jìn)腫瘤的侵襲、轉(zhuǎn)移和TGFβ的產(chǎn)生。IL13RA2的高表達(dá)與腫瘤的侵襲性、晚期階段和癌癥轉(zhuǎn)移相關(guān)，導(dǎo)致預(yù)后不良，特別是在膠質(zhì)母細(xì)胞瘤、結(jié)直腸癌和乳腺癌中。IL13RA2被視為癌癥治療的潛在靶點(diǎn)，尤其是在免疫治療和靶向治療領(lǐng)域。
熱銷產(chǎn)品
IL13RA2 Antibody (CSB-PA618901ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: Interleukin-13 receptor subunit alpha-2 antibody at 5μg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 44 kDa
Observed band size: 44 kDa
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA618901ESR1HU at dilution of 1:100
IL13RA2 Antibodies
IL13RA2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011592GA01HU | IL13RA2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA618901ESR1HU | IL13RA2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA618901ESR2HU | IL13RA2 Antibody | Human | ELISA, IHC |
| CSB-PA006276 | IL13RA2 Antibody | Human | WB, ELISA |
| CSB-PA009597 | IL13RA2 Antibody | Human | WB, ELISA |
| CSB-PA239289 | IL13RA2 Antibody | Human | ELISA,IHC |
| CSB-PA569374 | IL13RA2 Antibody | Human | ELISA,IHC |
IL13RA2 Proteins
IL13RA2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011592MO1 CSB-EP011592MO1 CSB-BP011592MO1 CSB-MP011592MO1 CSB-EP011592MO1-B |
Recombinant Mouse Interleukin-13 receptor subunit alpha-2 (Il13ra2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011592MO | Recombinant Mouse Interleukin-13 receptor subunit alpha-2 (Il13ra2) | in vitro E.coli expression system |
IL13RA2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP618901HU CSB-EP618901HU CSB-BP618901HU CSB-MP618901HU CSB-EP618901HU-B |
Recombinant Human Interleukin-13 receptor subunit alpha-2 (IL13RA2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL13RA2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP822098DO CSB-EP822098DO CSB-BP822098DO CSB-MP822098DO CSB-EP822098DO-B |
Recombinant Dog Interleukin-13 receptor subunit alpha-2 (IL13RA2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL13RA2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP855355RA CSB-EP855355RA CSB-BP855355RA CSB-MP855355RA CSB-EP855355RA-B |
Recombinant Rat Interleukin-13 receptor subunit alpha-2 (Il13ra2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
