ICOS
ICOS，即誘導(dǎo)型T細胞共刺激分子，別名CD278、AILIM，是一種I型跨膜糖蛋白，屬于CD28家族的共刺激免疫受體，通常在T細胞激活后迅速上調(diào)表達。
ICOS的作用機制涉及與其獨特配體（ICOS-L）在抗原呈遞細胞（APCs）上的相互作用，通過保守的細胞內(nèi)基序如YMFM、IProx和KKKY觸發(fā)細胞內(nèi)信號級聯(lián)反應(yīng)，促進T細胞激活和分化。ICOS在調(diào)節(jié)適應(yīng)性免疫反應(yīng)中扮演著關(guān)鍵角色，特別是在T輔助細胞（Tfh）的形成和體液免疫應(yīng)答中至關(guān)重要。ICOS基因的缺陷會導(dǎo)致體液免疫應(yīng)答嚴重受損。此外，ICOS還影響Th1、Th2和Th17免疫反應(yīng)以及調(diào)節(jié)性T細胞（Treg）的穩(wěn)態(tài)。ICOS/ICOS-L信號通路的調(diào)控在癌癥免疫治療和自身免疫疾病治療中具有巨大潛力。
熱銷產(chǎn)品
Recombinant Human Inducible T-cell costimulator (ICOS), partial (CSB-MP707478HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA123586(ICOS Antibody) at dilution 1/17, on the right is treated with fusion protein. (Original magnification: ×200)
ICOS Antibodies
ICOS for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA010957GA01HU | ICOS Antibody | Human | ELISA,WB |
| CSB-PA123586 | ICOS Antibody | Human | ELISA,IHC |
| CSB-PA745834 | ICOS Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
ICOS Proteins
ICOS Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP707478BO CSB-EP707478BO CSB-BP707478BO CSB-MP707478BO CSB-EP707478BO-B |
Recombinant Bovine Inducible T-cell costimulator (ICOS), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ICOS Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP771988DO CSB-EP771988DO CSB-BP771988DO CSB-MP771988DO CSB-EP771988DO-B |
Recombinant Dog Inducible T-cell costimulator (ICOS), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ICOS Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP889939RA CSB-BP889939RA CSB-MP889939RA CSB-EP889939RA-B |
Recombinant Rat Inducible T-cell costimulator (Icos), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP889939RA | Recombinant Rat Inducible T-cell costimulator (Icos), partial | E.coli |
ICOS Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP896269MO CSB-EP896269MO CSB-BP896269MO CSB-MP896269MO CSB-EP896269MO-B |
Recombinant Mouse Inducible T-cell costimulator (Icos), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ICOS Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-MP707478HU | Recombinant Human Inducible T-cell costimulator (ICOS), partial | Mammalian cell |
