HYAL2
透明質(zhì)酸酶2（Hyaluronidase 2，HYAL2）是人體內(nèi)降解透明質(zhì)酸的關(guān)鍵酶之一，常被稱為Hyal2或PH-20樣酶。該酶主要與HYAL1協(xié)同作用于溶酶體，將高分子量透明質(zhì)酸切割為20-25個(gè)糖單位的片段，其活性依賴于酸性環(huán)境。HYAL2可通過調(diào)控細(xì)胞外基質(zhì)重塑參與組織修復(fù)和腫瘤微環(huán)境形成，其異常表達(dá)與前列腺癌、膀胱癌等惡性腫瘤的侵襲轉(zhuǎn)移密切相關(guān)，在乳腺癌中還被發(fā)現(xiàn)能通過激活EGFR信號(hào)通路促進(jìn)耐藥性形成。HYAL2在心血管疾病領(lǐng)域也受到關(guān)注，其介導(dǎo)的透明質(zhì)酸降解可能影響動(dòng)脈粥樣硬化斑塊穩(wěn)定性。針對(duì)透明質(zhì)酸酶家族的藥物開發(fā)多聚焦于癌癥治療，例如新型小分子抑制劑SW-173T已進(jìn)入臨床前研究，可通過阻斷HYAL2活性抑制腫瘤細(xì)胞遷移。由于透明質(zhì)酸酶家族成員的功能冗余性，針對(duì)HYAL2的特異性靶向藥物仍面臨挑戰(zhàn)。
熱銷產(chǎn)品
Recombinant Human Hyaluronidase-2 (HYAL2) (CSB-MP618635HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
HYAL2 Antibody (CSB-PA618635ESR2HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: Hyaluronidase-2 antibody at 4μg/ml + Mouse lung tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA618635ESR2HU at dilution of 1:100
Human Hyaluronidase-2(HYAL2) ELISA kit (CSB-EL010919HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL010919HU
規(guī)格：96T/48T
靈敏度：0.078 ng/mL
檢測(cè)范圍：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
HYAL2 Antibodies
HYAL2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA010919GA01HU | HYAL2 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA618635ESR2HU | HYAL2 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA011966 | HYAL2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA014449 | HYAL2 Antibody | Human,Mouse,Rat | ELISA,IHC |
HYAL2 Proteins
HYAL2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP618635HU | Recombinant Human Hyaluronidase-2 (HYAL2) | Yeast |
| CSB-EP618635HU CSB-BP618635HU CSB-EP618635HU-B |
Recombinant Human Hyaluronidase-2 (HYAL2) | E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP618635HU | Recombinant Human Hyaluronidase-2 (HYAL2) | Mammalian cell |
HYAL2 ELISA Kit
HYAL2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL010919HU | Human Hyaluronidase-2(HYAL2) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
