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HUS1

Checkpoint protein HUS1 is a protein in humans that is encoded by HUS1 gene. Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates.

HUS1 Antibodies

HUS1 for Homo sapiens (Human)

HUS1 Proteins

HUS1 Proteins for Homo sapiens (Human)

HUS1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

HUS1 Proteins for Dictyostelium discoideum (Slime mold)

HUS1 Proteins for Mus musculus (Mouse)



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