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HSPA1A

HSPA1A,全稱為熱休克蛋白家族A成員1A(Heat Shock Protein Family A Member 1A),是一種重要的分子伴侶,在細(xì)胞應(yīng)激反應(yīng)中發(fā)揮著關(guān)鍵作用。它能夠幫助蛋白質(zhì)正確折疊,修復(fù)錯(cuò)誤折疊的蛋白質(zhì),并促進(jìn)蛋白質(zhì)復(fù)合物的形成與解離,從而維護(hù)蛋白質(zhì)組的完整性。HSPA1A蛋白也參與了細(xì)胞內(nèi)的信號傳導(dǎo)過程,影響細(xì)胞的生長、分化和凋亡。
HSPA1A蛋白的表達(dá)水平與多種疾病相關(guān),如癌癥、神經(jīng)退行性疾病和感染性疾病等。近年來,HSPA1A蛋白成為藥物研發(fā)的一個(gè)熱點(diǎn),研究人員正在探索其作為治療癌癥、神經(jīng)退行性疾病和感染性疾病的潛在靶點(diǎn)。例如,有研究顯示,HSPA1A蛋白可以抑制腫瘤細(xì)胞的增殖和轉(zhuǎn)移,并促進(jìn)腫瘤細(xì)胞的凋亡。此外,HSPA1A蛋白還可以增強(qiáng)免疫細(xì)胞的功能,幫助身體抵抗感染。因此,HSPA1A蛋白有望成為開發(fā)新型抗癌藥物和治療感染性疾病的潛在靶點(diǎn)。

熱銷產(chǎn)品

HSPA1A/HSPA1B Recombinant Monoclonal Antibody (CSB-RA151186A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA151186A0HU

Western Blot
Positive WB detected in: HEK293 whole cell lysate(30μg), U937 whole cell lysate(30μg), NIH/3T3 whole cell lysate(30μg)
All lanes: Hsp70 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 70 kDa
Observed band size: 70 kDa
Exposure time: 3min

CSB-RA151186A0HU

IHC image of CSB-RA151186A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA151186A0HU

Overlay Peak curve showing Hela cells stained with CSB-RA151186A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human Heat Shock Protein 72(HSP-72) ELISA Kit (CSB-E14916h)

驗(yàn)證數(shù)據(jù)

CSB-E14916h 標(biāo)準(zhǔn)曲線

貨號:CSB-E14916h

規(guī)格:96T/48T

靈敏度:0.78 ng/mL

檢測范圍:3.12 ng/mL-200 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

HSPA1A Antibodies

HSPA1A for Homo sapiens (Human)

HSPA1A ELISA Kit

HSPA1A ELISA Kit for Homo sapiens (Human)



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