HNRNPH1
HNRNPH1，全稱為異質(zhì)核核糖核蛋白H1，常用別名包括hnRNP H、HNRPH1等。作為細(xì)胞內(nèi)重要的RNA結(jié)合蛋白，它能與多種RNA分子結(jié)合，參與調(diào)控RNA的剪接、轉(zhuǎn)運(yùn)及穩(wěn)定性維持，在細(xì)胞正常生理活動中發(fā)揮核心作用。HNRNPH1異常表達(dá)或功能改變與多種疾病關(guān)聯(lián)緊密：在神經(jīng)系統(tǒng)中，它可能干擾神經(jīng)細(xì)胞的RNA代謝，與脆性X相關(guān)震顫/共濟(jì)失調(diào)綜合征等疾病的發(fā)生有關(guān)；在腫瘤領(lǐng)域，它的高表達(dá)常見于乳腺癌、肺癌等惡性腫瘤，或推動腫瘤細(xì)胞增殖與轉(zhuǎn)移。目前針對該蛋白的藥物研發(fā)尚處早期，科研人員正嘗試開發(fā)靶向其RNA結(jié)合活性的小分子抑制劑，或干擾其與其他分子的相互作用來調(diào)節(jié)功能，雖暫未進(jìn)入臨床階段，但為相關(guān)疾病治療提供了新的探索方向。
熱銷產(chǎn)品
Recombinant Human Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) (CSB-EP010609HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010609HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HNRNPH1.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010609HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HNRNPH1.
HNRNPH1 Monoclonal Antibody (CSB-MA058347)
驗證數(shù)據(jù)
Flow cytometric analysis of HNRNPH1 expression in HeLa cells using HNRNPH1 antibody. Green, isotype control; red, HNRNPH1.
Western blotting analysis using HNRNPH1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with HNRNPH1 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
HNRNPH1 Antibody (CSB-PA04264A0Rb)
驗證數(shù)據(jù)
Western blot
All lanes: HNRNPH1 antibody at 2µg/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 50 kDa
Observed band size: 36 kDa
HNRNPH1 Antibodies
HNRNPH1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA04264A0Rb | HNRNPH1 Antibody | Human | ELISA, WB |
| CSB-PA04264D0Rb | HNRNPH1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA010609GA01HU | HNRNPH1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA010609HD01HU | HNRNPH1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA010609HA01HU | HNRNPH1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA046570 | HNRNPH1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA786287 | HNRNPH1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-MA058347 | HNRNPH1 Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC |
HNRNPH1 Proteins
HNRNPH1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010609HU CSB-BP010609HU CSB-MP010609HU CSB-EP010609HU-B |
Recombinant Human Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP010609HU2 | Recombinant Human Heterogeneous nuclear ribonucleoprotein H (HNRNPH1), partial | E.coli |
| CSB-EP010609HU | Recombinant Human Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) | E.coli |
