HK2
HK2，即己糖激酶2，別名包括HKⅡ、HXK2。HK2由人類(lèi)HK2基因編碼。HK2是一種關(guān)鍵的代謝酶，主要定位在線粒體外膜上，負(fù)責(zé)催化糖酵解途徑中的第一步反應(yīng)，將葡萄糖磷酸化為6-磷酸葡萄糖。HK2在許多腫瘤中都呈現(xiàn)出高表達(dá)，在促進(jìn)Warburg效應(yīng)產(chǎn)生上起到重要作用，Warburg效應(yīng)即腫瘤細(xì)胞傾向于通過(guò)糖酵解而非氧化磷酸化來(lái)產(chǎn)生能量。HK2作為一個(gè)葡萄糖感受器，感應(yīng)細(xì)胞內(nèi)葡萄糖水平，通過(guò)經(jīng)典與非經(jīng)典的功能的轉(zhuǎn)換以連接能量代謝與腫瘤免疫，揭示了Warburg效應(yīng)促進(jìn)腫瘤免疫逃逸的機(jī)制。該研究不僅為癌癥的個(gè)體化治療揭示了新的代謝標(biāo)記物和分子靶點(diǎn)，而且對(duì)靶向腫瘤代謝和腫瘤免疫的藥物研發(fā)具有重要的指導(dǎo)意義。
熱銷(xiāo)產(chǎn)品
HK2 Antibody (CSB-PA010469LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: U87 whole cell lysate
All lanes: HK2 antibody at 4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 103 kDa
Observed band size: 103 kDa
Immunofluorescent analysis of PC-3 cells using CSB-PA010469LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
HK2 Antibodies
HK2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA611310 | HK2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA132121 | HK2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA010469LA01HU | HK2 Antibody | Human | ELISA, WB, IF |
| CSB-PA010469LB01HU | HK2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA010469LC01HU | HK2 Antibody, FITC conjugated | Human | |
| CSB-PA010469LD01HU | HK2 Antibody, Biotin conjugated | Human | ELISA |
HK2 Proteins
HK2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP010469RA CSB-EP010469RA CSB-BP010469RA CSB-MP010469RA CSB-EP010469RA-B |
Recombinant Rat Hexokinase-2 (Hk2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HK2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP010469HU CSB-EP010469HU CSB-BP010469HU CSB-MP010469HU CSB-EP010469HU-B |
Recombinant Human Hexokinase-2 (HK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HK2 Proteins for Equus caballus (Horse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP010469HO CSB-EP010469HO CSB-BP010469HO CSB-MP010469HO CSB-EP010469HO-B |
Recombinant Horse Hexokinase-2 (HK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HK2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP010469MO CSB-BP010469MO CSB-EP010469MO-B |
Recombinant Mouse Hexokinase-2 (Hk2), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
HK2 Proteins for Equus zebra (Mountain zebra)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP010469EJC CSB-EP010469EJC CSB-BP010469EJC CSB-MP010469EJC CSB-EP010469EJC-B |
Recombinant Equus zebra Hexokinase-2 (HK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HK2 Proteins for Equus grevyi (Grevy's zebra)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP010469EJB CSB-EP010469EJB CSB-BP010469EJB CSB-MP010469EJB CSB-EP010469EJB-B |
Recombinant Equus grevyi Hexokinase-2 (HK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HK2 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP633529PI CSB-EP633529PI CSB-BP633529PI CSB-MP633529PI CSB-EP633529PI-B |
Recombinant Pig Hexokinase-2 (HK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
