HAUS7

HAUS7，全稱為HAUS augmin like complex subunit 7，常見別名為26S proteasome-associated UCH interacting protein 1（UCHL5 interacting protein 1）。該蛋白在細(xì)胞分裂過程中發(fā)揮重要作用，是HAUS augmin-like復(fù)合物的一部分，參與有絲分裂紡錘體的組裝、中心體完整性的維持以及細(xì)胞分裂的完成。研究發(fā)現(xiàn)，HAUS7在睪丸和卵巢中的表達(dá)水平最高，并在脾臟、胸腺、精巢等組織中也有檢測(cè)到。此外，HAUS7還與食道鱗狀細(xì)胞癌（ESCC）的發(fā)生和發(fā)展有關(guān)，其與γ-微管蛋白的相互作用對(duì)ESCC細(xì)胞的生長(zhǎng)和存活至關(guān)重要。針對(duì)這一相互作用的治療抑制劑目前尚未出現(xiàn)，但已有研究證實(shí)，干擾這種相互作用可以有效抑制ESCC腫瘤的發(fā)生和發(fā)展。此外，HAUS7在神經(jīng)再生中也發(fā)揮重要作用，作為DOCK3的關(guān)鍵結(jié)合伴侶，通過調(diào)控微管組裝促進(jìn)軸突再生。在視神經(jīng)損傷后的軸突再生過程中，HAUS7的缺失會(huì)顯著抑制再生過程，這為青光眼等神經(jīng)退行性疾病的治療提供了新的靶點(diǎn)。目前，針對(duì)HAUS7的藥物研發(fā)主要集中在干擾其與γ-微管蛋白相互作用的治療抑制劑，以及增強(qiáng)HAUS7介導(dǎo)的微管穩(wěn)定性，以促進(jìn)神經(jīng)再生。

熱銷產(chǎn)品

HAUS7 Recombinant Monoclonal Antibody (CSB-RA565615A0HU)

驗(yàn)證數(shù)據(jù)

Flow cytometric analysis of HAUS7 expression in HepG2 cells using HAUS7 antibody. Green, isotype control; red, HAUS7.

Immunocytochemical staining of HepG2 cells with HAUS7?antibody. Nuclei were stained blue with DAPI; HAUS7?was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.

Western blotting analysis using HAUS7 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with HAUS7 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.

HAUS7 Antibody (CSB-PA994474)

驗(yàn)證數(shù)據(jù)

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA994474(HAUS7 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

HAUS7 Antibody

HAUS7 Protein

HAUS7 Antibodies

HAUS7 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-RA565615A0HU	HAUS7 Recombinant Monoclonal Antibody	Human	ELISA, WB, FC, ICC

HAUS7 Proteins

HAUS7 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP857461HU CSB-EP857461HU CSB-BP857461HU CSB-MP857461HU CSB-EP857461HU-B	Recombinant Human HAUS augmin-like complex subunit 7 (HAUS7)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli