H3L
H3L 蛋白全稱為組蛋白 H3 樣蛋白，也常被稱作 H3 樣變體、H3.3 樣組蛋白，是染色質(zhì)核小體的重要組成部分，參與 DNA 折疊、基因表達(dá)調(diào)控與細(xì)胞分化維持，在胚胎發(fā)育與神經(jīng)細(xì)胞成熟中尤為關(guān)鍵。它的結(jié)構(gòu)與功能異常會(huì)引發(fā)染色質(zhì)穩(wěn)態(tài)失衡，與兒童彌漫中線膠質(zhì)瘤、神經(jīng)發(fā)育障礙、Bryant-Li-Bhoj 綜合征等疾病密切相關(guān)，也在多種實(shí)體瘤的表觀遺傳紊亂中扮演重要角色。目前，針對(duì) H3L 相關(guān)異常的靶向藥物以表觀遺傳調(diào)節(jié)劑為主，甲基轉(zhuǎn)移酶抑制劑、組蛋白去乙?；敢种苿┑纫堰M(jìn)入臨床研究，同時(shí)靶向 H3 突變體的免疫治療與小分子精準(zhǔn)藥物也在快速推進(jìn)，為相關(guān)難治性疾病提供新的干預(yù)方向。
熱銷產(chǎn)品
Recombinant Vaccinia virus Envelope protein H3 (OPG108), partial (CSB-EP324943VAA1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
H3L Proteins
H3L Proteins for Vaccinia virus (strain Copenhagen) (VACV)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP324943VAA1 CSB-BP324943VAA1 CSB-MP324943VAA1 CSB-EP324943VAA1-B |
Recombinant Vaccinia virus Envelope protein H3 (OPG108), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF324943VAA | Recombinant Vaccinia virus Envelope protein H3 (H3L) | in vitro E.coli expression system |
| CSB-EP324943VAA1 | Recombinant Vaccinia virus Envelope protein H3 (OPG108), partial | E.coli |
| CSB-EP324943VAA1d7 | Recombinant Vaccinia virus Envelope protein H3 (OPG108), partial | E.coli |
