GPR119
GPR119，即G蛋白偶聯(lián)受體119，別名Glucose-dependent insulinotropic receptor，是一種G蛋白偶聯(lián)受體（GPCR）超家族中的孤兒受體，主要分布在胰島β細(xì)胞和胃腸道L細(xì)胞。GPR119的作用機(jī)制是通過與內(nèi)源性配體如油酰乙醇酰胺和其他含有油酸的內(nèi)源性脂質(zhì)結(jié)合來(lái)激活，進(jìn)而刺激胰高血糖素樣肽-1（GLP-1）和葡萄糖依賴性促胰島素釋放多肽（GIP）的分泌，這兩種激素對(duì)于調(diào)控體內(nèi)糖代謝平衡具有重要作用。GPR119的激活可以促進(jìn)葡萄糖依賴的胰島素分泌，增加腸道分泌的腸促胰島素激素，是治療糖尿病、脂肪肝和肥胖癥等代謝性疾病的潛在藥物靶點(diǎn)。
熱銷產(chǎn)品
GPR119 Antibody (CSB-PA007283)
驗(yàn)證數(shù)據(jù)
Western Blot analysis of COLO cells using GPR119 Polyclonal Antibody
Western blot analysis of SH-SY5Y mouse-kidney lysis using GPR119 antibody.
GPR119 Antibodies
GPR119 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA007283 | GPR119 Antibody | Human | WB, IF, ELISA |
GPR119 Proteins
GPR119 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP752652RA1 CSB-EP752652RA1 CSB-BP752652RA1 CSB-MP752652RA1 CSB-EP752652RA1-B |
Recombinant Rat Glucose-dependent insulinotropic receptor (Gpr119), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF752652RA | Recombinant Rat Glucose-dependent insulinotropic receptor (Gpr119) | in vitro E.coli expression system |
GPR119 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP766514MO1 CSB-EP766514MO1 CSB-BP766514MO1 CSB-MP766514MO1 CSB-EP766514MO1-B |
Recombinant Mouse Glucose-dependent insulinotropic receptor (Gpr119), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF766514MO | Recombinant Mouse Glucose-dependent insulinotropic receptor (Gpr119) | in vitro E.coli expression system |
GPR119 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP840575HU1 CSB-EP840575HU1 CSB-BP840575HU1 CSB-MP840575HU1 CSB-EP840575HU1-B |
Recombinant Human Glucose-dependent insulinotropic receptor (GPR119), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF840575HU | Recombinant Human Glucose-dependent insulinotropic receptor (GPR119) | in vitro E.coli expression system |
