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Your Good Partner in Biology Research

FOSL1

FOSL1(FOS-like antigen 1)又稱Fra-1,屬于AP-1轉(zhuǎn)錄因子家族成員,在細(xì)胞增殖、分化和凋亡中發(fā)揮調(diào)控作用。FOSL1通過與JUN家族蛋白形成二聚體,結(jié)合特定DNA序列激活下游靶基因,尤其與腫瘤侵襲轉(zhuǎn)移密切相關(guān)。有研究發(fā)現(xiàn),F(xiàn)OSL1在乳腺癌、結(jié)直腸癌和肺癌等多種惡性腫瘤中異常高表達(dá),通過誘導(dǎo)上皮間質(zhì)轉(zhuǎn)化(EMT)促進(jìn)癌細(xì)胞遷移,并與血管生成、化療耐藥等惡性表型相關(guān)。其活性受MAPK/ERK和JNK等信號(hào)通路調(diào)控,與炎癥因子TNF-α、IL-6的表達(dá)也存在交叉調(diào)控。目前針對(duì)FOSL1尚無直接靶向藥物,但針對(duì)其上游信號(hào)分子開發(fā)的MEK抑制劑(如曲美替尼)已在臨床試驗(yàn)中驗(yàn)證對(duì)部分腫瘤的療效。近年研究發(fā)現(xiàn),天然化合物姜黃素可通過抑制FOSL1表達(dá)延緩腫瘤進(jìn)展,為聯(lián)合用藥提供了新方向。

熱銷產(chǎn)品

FOSL1 Antibody (CSB-PA008792DSR1HU)

驗(yàn)證數(shù)據(jù)

CSB-PA008792DSR1HU

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA008792DSR1HU at dilution of 1:100

CSB-PA008792DSR1HU

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA008792DSR1HU at dilution of 1:100

CSB-PA008792DSR1HU

Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA008792DSR1HU at dilution of 1:100

FOSL1 Antibodies

FOSL1 for Homo sapiens (Human)

FOSL1 Proteins

FOSL1 Proteins for Rattus norvegicus (Rat)

FOSL1 Proteins for Homo sapiens (Human)

FOSL1 Proteins for Mus musculus (Mouse)



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