FGF23
FGF23，全稱為成纖維細(xì)胞生長因子23，是一種由骨細(xì)胞分泌的激素，在調(diào)節(jié)體內(nèi)磷酸鹽和維生素D的平衡中發(fā)揮著關(guān)鍵作用。它主要通過抑制腎臟對磷酸鹽的再吸收，以及減少活性維生素D的產(chǎn)生，從而降低血液中的磷酸鹽和維生素D水平。FGF23的常見別名包括FGF-23。FGF23主要與X-連鎖低磷血癥（XLH）和腫瘤誘導(dǎo)性骨軟化癥（TIO）等疾病相關(guān)。在XLH患者中，由于PHEX基因突變導(dǎo)致骨細(xì)胞產(chǎn)生過多的FGF23，進(jìn)而引起低磷血癥和骨骼畸形。而在TIO患者中，腫瘤細(xì)胞分泌的FGF23導(dǎo)致尿液中磷酸鹽大量消耗，同樣引起低磷血癥和骨軟化。針對FGF23的藥物研發(fā)主要集中在開發(fā)抗FGF23抗體，以抑制其活性，從而提高血液中的磷酸鹽和維生素D水平。例如，日本Kyowa Hakko Kirin公司開發(fā)的抗FGF23抗體burosumab（商品名Crysvita）是全球首個(gè)治療XLH的藥物，也被批準(zhǔn)用于治療TIO。此外，還有其他抗FGF23抗體正在研發(fā)中，有望為更多FGF23相關(guān)疾病患者帶來新的治療選擇。
熱銷產(chǎn)品
Recombinant Human Fibroblast growth factor 23 (FGF23), partial (CSB-EP008629HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Human fibroblast growth factor-23,FGF-23 ELISA Kit (CSB-E10113h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E10113h
規(guī)格：96T/48T
靈敏度：0.78 pg/mL
檢測范圍：3.12 pg/mL-200 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
FGF23 Antibodies
FGF23 for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA008629LA01RA | Fgf23 Antibody | Rat | ELISA, WB |
| CSB-PA008629LB01RA | Fgf23 Antibody, HRP conjugated | Rat | ELISA |
| CSB-PA008629LD01RA | Fgf23 Antibody, Biotin conjugated | Rat | ELISA |
FGF23 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA163892 | FGF23 Antibody | Human,Mouse | ELISA,WB,IF |
| CSB-PA005032 | FGF23 Antibody | Human | WB, ELISA |
| CSB-PA060188 | FGF23 Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA13919A0Rb | FGF23 Antibody | Human | ELISA, IF |
| CSB-PA13919B0Rb | FGF23 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA13919C0Rb | FGF23 Antibody, FITC conjugated | Human | |
| CSB-PA13919D0Rb | FGF23 Antibody, Biotin conjugated | Human | ELISA |
FGF23 Proteins
FGF23 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008629RA | Recombinant Rat Fibroblast growth factor 23 (Fgf23) | Yeast |
| CSB-EP008629RA | Recombinant Rat Fibroblast growth factor 23 (Fgf23) | E.coli |
| CSB-BP008629RA CSB-MP008629RA CSB-EP008629RA-B |
Recombinant Rat Fibroblast growth factor 23 (Fgf23) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGF23 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008629MO CSB-EP008629MO CSB-BP008629MO CSB-MP008629MO CSB-EP008629MO-B |
Recombinant Mouse Fibroblast growth factor 23 (Fgf23) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGF23 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008629HU CSB-BP008629HU CSB-MP008629HU CSB-EP008629HU-B |
Recombinant Human Fibroblast growth factor 23 (FGF23) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP002481HU | Recombinant Human Fibroblast growth factor 23 protein (FGF23) (Active) | E.Coli |
| CSB-EP008629HU | Recombinant Human Fibroblast growth factor 23 (FGF23), partial | E.coli |
FGF23 Proteins for Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008629TCA CSB-EP008629TCA CSB-BP008629TCA CSB-MP008629TCA CSB-EP008629TCA-B |
Recombinant Tetraodon nigroviridis Fibroblast growth factor 23 (fgf23) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGF23 ELISA Kit
FGF23 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E10113h | Human fibroblast growth factor-23,FGF-23 ELISA Kit | serum, cell culture supernates, urine, tissue homogenates | 0.78 pg/mL |
FGF23 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL008629MO | Mouse Fibroblast growth factor 23(FGF23) ELISA kit | serum, plasma, tissue homogenates | 5.86 pg/mL |
FGF23 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12170r | Rat fibroblast growth factor 23 (FGF23) ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.39 pg/mL |
| CSB-E12170r(1) | Rat fibroblast growth factor 23 (FGF23) ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 3.9 ng/mL |
