FCRL6
FCRL6，全稱Fc受體樣蛋白6，也常被稱為FCRH6或CD307h，是免疫細(xì)胞表面的一種分子。它主要存在于活化的T細(xì)胞、NK細(xì)胞及部分淋巴細(xì)胞亞群上，當(dāng)與特定配體結(jié)合時，會影響細(xì)胞的活化狀態(tài)，幫助調(diào)控免疫應(yīng)答的強度，避免免疫反應(yīng)過度。研究發(fā)現(xiàn)，F(xiàn)CRL6在一些淋巴瘤（如外周T細(xì)胞淋巴瘤）患者的腫瘤細(xì)胞上高表達(dá)，也與類風(fēng)濕關(guān)節(jié)炎等自身免疫病的免疫失衡相關(guān)——這類患者體內(nèi)免疫細(xì)胞常異常激活，F(xiàn)CRL6的表達(dá)變化可能參與其中。目前，針對FCRL6的單克隆抗體正處于早期研發(fā)階段，這些抗體試圖通過靶向腫瘤細(xì)胞表面的FCRL6來誘導(dǎo)細(xì)胞死亡，或增強免疫細(xì)胞對腫瘤的攻擊，部分候選藥物已進(jìn)入臨床前研究，有望為相關(guān)疾病提供新治療方向。
熱銷產(chǎn)品
Recombinant Human Fc receptor-like protein 6 (FCRL6), partial (CSB-EP718779HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP718779HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) FCRL6.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP718779HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) FCRL6.
FCRL6 Antibody (CSB-PA718779ESR2HU)
驗證數(shù)據(jù)
Western blot
All lanes: FCRL6 antibody at 1.29μg/ml
Lane 1: Hela whole cell lysate
Lane 2: A549 whole cell lysate
Lane 3: Jurkat whole cell lysate
Lane 4: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 48, 46, 44, 35 kDa
Observed band size: 48 kDa
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA718779ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA718779ESR2HU at dilution of 1:100
FCRL6 Antibodies
FCRL6 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA718779LA01HU | FCRL6 Antibody | Human | ELISA |
| CSB-PA718779LB01HU | FCRL6 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA718779LC01HU | FCRL6 Antibody, FITC conjugated | Human | |
| CSB-PA718779LD01HU | FCRL6 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA718779ESR2HU | FCRL6 Antibody | Human | ELISA, WB, IHC |
FCRL6 Proteins
FCRL6 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008559MO1 CSB-EP008559MO1 CSB-BP008559MO1 CSB-MP008559MO1 CSB-EP008559MO1-B |
Recombinant Mouse Fc receptor-like protein 6 (Fcrl6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF008559MO | Recombinant Mouse Fc receptor-like protein 6 (Fcrl6) | in vitro E.coli expression system |
FCRL6 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP718779HU | Recombinant Human Fc receptor-like protein 6 (FCRL6), partial | Yeast |
| CSB-EP718779HU | Recombinant Human Fc receptor-like protein 6 (FCRL6), partial | E.coli |
| CSB-BP718779HU | Recombinant Human Fc receptor-like protein 6 (FCRL6), partial | Baculovirus |
| CSB-MP718779HU | Recombinant Human Fc receptor-like protein 6 (FCRL6), partial | Mammalian cell |
