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Your Good Partner in Biology Research

FADS1

FADS1,全稱為脂肪酸去飽和酶1,常被稱為Δ-5去飽和酶。它在人體脂肪酸代謝中發(fā)揮關(guān)鍵作用,能將亞油酸等普通不飽和脂肪酸轉(zhuǎn)化為花生四烯酸這類身體必需的活性成分——這些成分不僅構(gòu)成細(xì)胞膜的重要部分,影響細(xì)胞彈性與物質(zhì)交換,還參與炎癥反應(yīng)、激素合成等生理過程的調(diào)控。
FADS1活性異常,可能打破體內(nèi)脂肪酸平衡,與高血脂、2型糖尿病、動(dòng)脈粥樣硬化等代謝及心血管問題相關(guān),部分炎癥性疾病如類風(fēng)濕關(guān)節(jié)炎的發(fā)生也可能與其功能失調(diào)有關(guān)。目前科研人員正探索調(diào)節(jié)其活性的物質(zhì),希望借此改善代謝紊亂或炎癥狀態(tài),這類研究多處于實(shí)驗(yàn)室或早期臨床試驗(yàn)階段。

熱銷產(chǎn)品

FADS1 Recombinant Monoclonal Antibody (CSB-RA155442A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA155442A0HU

Western Blot
Positive WB detected in: MCF-7 whole cell lysate, A549 whole cell lysate, Hela whole cell lysate
All lanes: FADS1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 43 kDa
Observed band size: 55 kDa

CSB-RA155442A0HU

IHC image of CSB-RA155442A0HU diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA155442A0HU

Immunofluorescence staining of HepG2 cell with CSB-RA155442A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 565-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA155442A0HU

Overlay Peak curve showing HepG2 cells stained with CSB-RA155442A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

FADS1 Antibody (CSB-PA007959LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA007959LA01HU

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA007959LA01HU at dilution of 1:100

CSB-PA007959LA01HU

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA007959LA01HU at dilution of 1:100

CSB-PA007959LA01HU

Immunofluorescent analysis of HepG2 cells using CSB-PA007959LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CSB-PA007959LA01HU

Western Blot
Positive WB detected in: Hela whole cell lysate, SH-SY5Y whole cell lysate
All lanes: FADS1 antibody at 3.4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 43 kDa
Observed band size: 52 kDa

FADS1 Antibodies

FADS1 for Homo sapiens (Human)

FADS1 Proteins

FADS1 Proteins for Homo sapiens (Human)



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