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FADD

FADD,全稱為FAS-associated death domain protein,是一種參與細(xì)胞凋亡調(diào)控的重要蛋白。它也被稱為Fas-associating death domain-containing protein或Fas-associating protein with death domain。FADD蛋白在細(xì)胞凋亡過程中發(fā)揮著關(guān)鍵作用,它能夠與Fas受體結(jié)合,形成死亡誘導(dǎo)信號復(fù)合物,進(jìn)而激活下游的凋亡通路。
FADD蛋白與多種疾病相關(guān),包括自身免疫性疾病、癌癥和感染性疾病等。在自身免疫性疾病中,F(xiàn)ADD蛋白的異常表達(dá)或功能失調(diào)可能導(dǎo)致免疫系統(tǒng)攻擊自身組織,引發(fā)炎癥和組織損傷。在癌癥中,F(xiàn)ADD蛋白的異常表達(dá)或功能失調(diào)可能與腫瘤細(xì)胞的生長和擴(kuò)散有關(guān)。在感染性疾病中,F(xiàn)ADD蛋白可能參與免疫應(yīng)答的調(diào)控,影響機(jī)體對病原體的清除能力。
針對FADD蛋白的藥物研發(fā)取得了一定的進(jìn)展。例如,Z-VAD-FMK是一種廣譜性Caspase抑制劑,可以抑制FADD蛋白介導(dǎo)的細(xì)胞凋亡,用于治療癌癥和自身免疫性疾病。此外,還有多種靶向FADD蛋白的小分子抑制劑和抗體正在研發(fā)中,用于治療癌癥、自身免疫性疾病和感染性疾病等。

熱銷產(chǎn)品

Recombinant Human FAS-associated death domain protein (FADD) (CSB-EP623788HU)

驗證數(shù)據(jù)

CSB-EP623788HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FADD Recombinant Monoclonal Antibody (CSB-RA158850A0HU)

驗證數(shù)據(jù)

CSB-RA158850A0HU

Western Blot
Positive WB detected in: A549 whole cell lysate(20μg),Hela whole cell lysate(20μg), Jurkat whole cell lysate(20μg),NIH/3T3 whole cell lysate(20μg)
All lanes: FADD antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 23 kDa
Observed band size: 25 kDa
Exposure time:2min

CSB-RA158850A0HU

Overlay Peak curve showing HepG2 cells stained with CSB-RA158850A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

FADD Antibody (CSB-PA824751)

驗證數(shù)據(jù)

CSB-PA824751

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA824751(FADD Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA824751

The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA824751(FADD Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA824751

Gel: 8+12%SDS-PAGE, Lysate: 30 μg, Lane 1-2: Mouse spleen tissue, RAW264.7 cells, Primary antibody: CSB-PA824751(FADD Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds

Human Protein FADD(FADD) ELISA kit (CSB-EL007958HU)

驗證數(shù)據(jù)

CSB-EL007958HU 標(biāo)準(zhǔn)曲線

貨號:CSB-EL007958HU

規(guī)格:96T/48T

靈敏度:31.25 pg/mL

檢測范圍:125 pg/mL-8000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

FADD Antibodies

FADD for Homo sapiens (Human)

FADD for Mus musculus (Mouse)

FADD Proteins

FADD Proteins for Escherichia coli (strain K12)

FADD Proteins for Escherichia coli O6

FADD Proteins for Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

FADD Proteins for Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

FADD Proteins for Salmonella typhi

FADD Proteins for Homo sapiens (Human)

FADD Proteins for Drosophila pseudoobscura pseudoobscura (Fruit fly)

FADD Proteins for Mus musculus (Mouse)

FADD Proteins for Bos taurus (Bovine)

FADD Proteins for Escherichia coli O157:H7

FADD Proteins for Yersinia pestis

FADD Proteins for Drosophila melanogaster (Fruit fly)

FADD ELISA Kit

FADD ELISA Kit for Homo sapiens (Human)



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