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F11

F11蛋白,全稱為凝血因子XI,是一種參與血液凝固過程的血漿蛋白。它以酶原形式存在,通過二硫鍵連接形成同源二聚體。F11蛋白在凝血級(jí)聯(lián)反應(yīng)中發(fā)揮著關(guān)鍵作用,能夠激活因子IX,進(jìn)而觸發(fā)血液凝固的內(nèi)源性途徑。F11蛋白的激活形式F11a能夠促進(jìn)因子IX的活性,從而加速凝血過程。
F11蛋白的常見別名包括Factor XI concentrate、Factor XI deficiency等。F11蛋白參與多種生理和病理過程,包括血液凝固、炎癥反應(yīng)和細(xì)胞凋亡等。F11蛋白的異常激活或抑制與多種疾病相關(guān),如血栓性疾病、炎癥性疾病和腫瘤等。
目前,針對(duì)F11蛋白的藥物研發(fā)主要集中在血栓性疾病領(lǐng)域。例如,一些小分子抑制劑能夠抑制F11蛋白的活性,從而阻止血栓的形成。此外,一些抗體藥物能夠靶向F11蛋白,從而抑制血液凝固過程。這些藥物在治療血栓性疾病方面展現(xiàn)出良好的療效,并處于臨床研發(fā)的不同階段。
總之,F(xiàn)11蛋白是一種重要的血漿蛋白,參與血液凝固過程。F11蛋白的異常激活或抑制與多種疾病相關(guān),針對(duì)F11蛋白的藥物研發(fā)在治療血栓性疾病方面具有重要的應(yīng)用價(jià)值。

熱銷產(chǎn)品

Recombinant Human Coagulation factor XI (F11) (Active) (CSB-MP007916HU(A4))

驗(yàn)證數(shù)據(jù)

CSB-MP007916HU(A4)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP007916HU(A4)

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human F11 at 2 μg/ml can bind Anti-F11 recombinant antibody (CSB-RA007916MA1HU). The EC50 is 0.2442-0.2820 ng/mL.

CSB-MP007916HU(A4)

Activity
Measured by its ability to cleave the fluorogenic peptide substrate, t-butyloxycarbonyl-Ile-Glu-Gly-Arg-7-amido-4-methylcoumarin (Boc-IEGR-AMC). The specific activity is >300 pmol/min/μg.

Recombinant Macaca mulatta Coagulation factor XI (Active) (CSB-MP5433MOW)

驗(yàn)證數(shù)據(jù)

CSB-MP5433MOW

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP5433MOW

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca mulatta F11 at 2 μg/ml can bind Anti-F11 recombinant antibody (CSB-RA007916MA1HU). The EC50 is 0.5654-0.6444 ng/mL.

CSB-MP5433MOW

Activity
Measured by its ability to cleave the fluorogenic peptide substrate, t-butyloxycarbonyl-Ile-Glu-Gly-Arg-7-amido-4-methylcoumarin (Boc-IEGR-AMC). The specific activity is >150 pmol/min/μg.

CSB-MP5433MOW

The purity of TrEMBL was greater than 95% as determined by SEC-HPLC

Recombinant Human Coagulation factor XI (F11), partial (CSB-EP007916HU)

驗(yàn)證數(shù)據(jù)

CSB-EP007916HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

F11 Recombinant Monoclonal Antibody (CSB-RA007916MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA007916MA1HU

The Binding Activity of Macaca mulatta F11 with Anti-F11 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca mulatta F11 (CSB-MP5433MOW) at 2 μg/mL can bind Anti-F11 recombinant antibody. The EC50 is 0.5654-0.6444 ng/mL.

CSB-RA007916MA1HU

The Binding Activity of Human F11 with Anti-F11 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human F11 (CSB-MP010949HU) at 2 μg/mL can bind Anti-F11 recombinant antibody. The EC50 is 0.2442-0.2820 ng/mL.

Human Coagulation factor XI(F11) ELISA kit (CSB-EL007916HU)

驗(yàn)證數(shù)據(jù)

CSB-EL007916HU 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-EL007916HU

規(guī)格:96T/48T

靈敏度:19.5 pg/mL

檢測(cè)范圍:78 pg/mL-5000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

F11 Antibodies

F11 for Homo sapiens (Human)

F11 Proteins

F11 Proteins for Homo sapiens (Human)

F11 Proteins for Vaccinia virus (strain L-IVP) (VACV)

F11 Proteins for Mus musculus (Mouse)

F11 Proteins for Bos taurus (Bovine)

F11 ELISA Kit

F11 ELISA Kit for Homo sapiens (Human)

F11 ELISA Kit for Mus musculus (Mouse)



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