EREG
表皮調(diào)節(jié)素（Epiregulin，簡(jiǎn)稱EREG）是表皮生長(zhǎng)因子家族成員之一，也被稱為ER或EPR。該蛋白通過(guò)與細(xì)胞表面受體結(jié)合，觸發(fā)胞內(nèi)級(jí)聯(lián)反應(yīng)，廣泛參與組織修復(fù)、胚胎發(fā)育及腫瘤微環(huán)境調(diào)控。研究發(fā)現(xiàn)，表皮調(diào)節(jié)素在多種實(shí)體瘤中異常高表達(dá)，例如結(jié)直腸癌、乳腺癌及非小細(xì)胞肺癌中，其過(guò)量分泌會(huì)加速惡性細(xì)胞增殖與侵襲，同時(shí)誘導(dǎo)血管生成，為腫瘤轉(zhuǎn)移提供條件。此外，該蛋白在炎癥性腸病、銀屑病等慢性炎癥疾病中同樣呈現(xiàn)活躍狀態(tài)，可能與免疫細(xì)胞異常激活有關(guān)。
目前針對(duì)表皮調(diào)節(jié)素的藥物研發(fā)聚焦于單克隆抗體和受體抑制劑領(lǐng)域。例如，西妥昔單抗等EGFR靶向藥物可間接干擾表皮調(diào)節(jié)素的功能，已在結(jié)直腸癌治療中取得臨床驗(yàn)證。近期研究還發(fā)現(xiàn)，部分小分子化合物能選擇性阻斷表皮調(diào)節(jié)素與其受體的結(jié)合，在小鼠模型中顯著抑制腫瘤生長(zhǎng)。此外，基于該蛋白與免疫檢查點(diǎn)的關(guān)聯(lián)，聯(lián)合免疫療法的探索也進(jìn)入早期臨床試驗(yàn)階段。
熱銷產(chǎn)品
Recombinant Human Proepiregulin (EREG), partial (CSB-EP007779HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
Immunohistochemical analysis of paraffin-embedded Human-liver, antibody was diluted at 1:100
Human epiregulin (EREG) ELISA kit (CSB-EL007779HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL007779HU
規(guī)格：96T/48T
靈敏度：3.9 pg/mL
檢測(cè)范圍：15.6 pg/mL-1000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
EREG Antibodies
EREG for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA189260 | EREG Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA007779NA01HU | EREG Antibody | Human | ELISA, IF |
| CSB-PA007779PA01HU | EREG Antibody | Human | ELISA, IF |
| CSB-PA007779ND01HU | EREG Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA007779PD01HU | EREG Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA007779NC01HU | EREG Antibody, FITC conjugated | Human | |
| CSB-PA007779PC01HU | EREG Antibody, FITC conjugated | Human | |
| CSB-PA007779NB01HU | EREG Antibody, HRP conjugated | Human | ELISA |
| CSB-PA007779PB01HU | EREG Antibody, HRP conjugated | Human | ELISA |
EREG Proteins
EREG Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP007779HU CSB-BP007779HU CSB-MP007779HU CSB-EP007779HU-B |
Recombinant Human Proepiregulin (EREG), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP002621HU | Recombinant?Human?Proepiregulin (EREG), partial? (Active) | E.Coli |
| CSB-EP007779HU | Recombinant Human Proepiregulin (EREG), partial | E.coli |
| CSB-CF007779HU | Recombinant Human Proepiregulin (EREG) | in vitro E.coli expression system |
EREG Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP730741MO CSB-BP730741MO CSB-EP730741MO-B |
Recombinant Mouse Proepiregulin (Ereg), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
EREG ELISA Kit
EREG ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL007779HU | Human epiregulin (EREG) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 3.9 pg/mL |
