ENG

ENG全稱為內(nèi)皮聯(lián)蛋白（Endoglin），別名CD105。它是一種I型跨膜糖蛋白，主要表達(dá)于內(nèi)皮細(xì)胞、成纖維細(xì)胞和血管平滑肌細(xì)胞等。內(nèi)皮聯(lián)蛋白作為T(mén)GF-β家族的輔助受體，通過(guò)與TGF-β受體復(fù)合體相互作用，調(diào)節(jié)細(xì)胞的增殖、遷移和分化，從而在血管生成和穩(wěn)態(tài)維持中發(fā)揮關(guān)鍵作用。內(nèi)皮聯(lián)蛋白還參與炎癥反應(yīng)和免疫應(yīng)答的調(diào)節(jié)。
ENG基因突變可導(dǎo)致1型遺傳性出血性毛細(xì)血管擴(kuò)張癥（HHT1），表現(xiàn)為血管發(fā)育不良和反復(fù)出血。在腫瘤中，內(nèi)皮聯(lián)蛋白高表達(dá)與腫瘤血管生成和轉(zhuǎn)移密切相關(guān)，因此成為抗腫瘤治療的重要靶點(diǎn)。針對(duì)內(nèi)皮聯(lián)蛋白的藥物研發(fā)正在推進(jìn)，旨在通過(guò)抑制其功能來(lái)阻斷腫瘤血管生成。

熱銷產(chǎn)品

ENG Antibody (CSB-PA400072)

驗(yàn)證數(shù)據(jù)

Western blot analysis of K562 3T3 lysate, antibody was diluted at 500. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded human-tonsil, antibody was diluted at 1:200

Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200

ENG Antibody

ENG Protein

ENG ELISA Kit

ENG Antibodies

ENG for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA007667GA01HU	ENG Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA400072	ENG Antibody	Human	WB, IHC, ELISA
CSB-PA007667LA01HU	ENG Antibody	Human	ELISA, IF
CSB-PA007667LC01HU	ENG Antibody, FITC conjugated	Human
CSB-PA007667LD01HU	ENG Antibody, Biotin conjugated	Human	ELISA
CSB-MA294403	ENG Monoclonal Antibody	Human	ELISA, IHC

ENG Proteins

ENG Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP007667HU1 CSB-EP007667HU1 CSB-BP007667HU1 CSB-MP007667HU1 CSB-EP007667HU1-B	Recombinant Human Endoglin (ENG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF007667HU	Recombinant Human Endoglin (ENG)	in vitro E.coli expression system

ENG Proteins for Sus scrofa (Pig)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP007667PI1 CSB-EP007667PI1 CSB-BP007667PI1 CSB-MP007667PI1 CSB-EP007667PI1-B	Recombinant Pig Endoglin (ENG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF007667PI	Recombinant Pig Endoglin (ENG)	in vitro E.coli expression system

ENG Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP007667MO CSB-EP007667MO CSB-BP007667MO CSB-MP007667MO CSB-EP007667MO-B	Recombinant Mouse Endoglin (Eng), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli