ELAVL4
ELAVL4，全稱為ELAV樣RNA結(jié)合蛋白4，常用別名是HuD。它是一種主要分布在神經(jīng)系統(tǒng)中的RNA結(jié)合蛋白，與神經(jīng)細(xì)胞的發(fā)育、成熟及突觸功能的維持密切相關(guān)。正常情況下，HuD能幫助某些神經(jīng)相關(guān)的遺傳信息分子保持穩(wěn)定，確保這些分子順利轉(zhuǎn)化為蛋白質(zhì)，從而支持神經(jīng)細(xì)胞的生長(zhǎng)分化和信號(hào)傳遞。
當(dāng)HuD的表達(dá)或功能出現(xiàn)異常時(shí)，可能與多種疾病相關(guān)。比如阿爾茨海默病患者的腦組織中，HuD的水平常發(fā)生變化，影響神經(jīng)細(xì)胞的正常運(yùn)作；在神經(jīng)母細(xì)胞瘤等腫瘤中，它的異常表達(dá)也可能促進(jìn)腫瘤細(xì)胞的增殖。目前，科研人員正在探索調(diào)控HuD活性的策略，例如通過(guò)小分子化合物或核酸類物質(zhì)調(diào)整其功能，希望為相關(guān)疾病的治療提供新方向。
熱銷產(chǎn)品
Recombinant Human ELAV-like protein 4 (ELAVL4) (CSB-EP007595HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ELAVL4 Antibody (CSB-PA007595LA01HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: ELAVL4 antibody at 2µg/ml
Lane 1: MCF-7 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 42, 41, 43 kDa
Observed band size: 42 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA007595LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA007595LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA007595LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
ELAVL4 Antibodies
ELAVL4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA007595GA01HU | ELAVL4 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA007595LA01HU | ELAVL4 Antibody | Human | ELISA, WB, IHC, IF |
ELAVL4 Proteins
ELAVL4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP007595HU CSB-BP007595HU CSB-MP007595HU CSB-EP007595HU-B |
Recombinant Human ELAV-like protein 4 (ELAVL4) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
