DNM1L
DNM1L，全名為動(dòng)力蛋白相關(guān)蛋白1（Drp1），是發(fā)動(dòng)蛋白超家族的成員，最早在酵母中發(fā)現(xiàn)，故又名 DNM1。該蛋白參與線(xiàn)粒體和過(guò)氧化物酶體的分裂、線(xiàn)粒體的運(yùn)輸和分布等過(guò)程，對(duì)維持線(xiàn)粒體正常功能至關(guān)重要。當(dāng) DNM1L 發(fā)生突變時(shí)，會(huì)導(dǎo)致線(xiàn)粒體形態(tài)異常、功能受損，進(jìn)而引起能量生成不足，影響心肌細(xì)胞收縮和舒張功能，引發(fā)心肌功能障礙。研究表明，DNM1L 突變與擴(kuò)張型心肌病、癲癇、腦病等多種疾病相關(guān)。目前，針對(duì) DNM1L 相關(guān)疾病的研究主要集中在闡明其突變導(dǎo)致的病理機(jī)制，以及探索新的治療策略。已有研究表明，通過(guò)基因編輯技術(shù)構(gòu)建遺傳背景相似的對(duì)照細(xì)胞系，可以進(jìn)一步探究突變位點(diǎn)與疾病嚴(yán)重程度的關(guān)系，為開(kāi)發(fā)針對(duì)此類(lèi)疾病的新療法提供重要依據(jù)。
熱銷(xiāo)產(chǎn)品
Recombinant Human Dynamin-1-like protein (DNM1L) (CSB-EP007078HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP007078HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) DNM1L.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP007078HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) DNM1L.
DNM1L Antibody (CSB-PA007078EA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: A549 whole cell lysate, Mouse heart tissue
All lanes: DNM1L antibody at 0.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 82, 81, 80, 79, 84, 61, 83 kDa
Observed band size: 82 kDa
Immunohistochemistry analysis of human cervical cancer using CSB-PA007078EA01HU at dilution of 1:100
Immunohistochemistry analysis of human brain tissue using CSB-PA007078EA01HU at dilution of 1:100
DNM1L Antibodies
DNM1L for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA007078GA01HU | DNM1L Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA297783 | Phospho-DNM1L (Ser637) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA825071 | DNM1L (Ab-637) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA002203 | DNM1L Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA006377 | Phospho-DNM1L (S637) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA007078EA01HU | DNM1L Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA007078EB01HU | DNM1L Antibody, HRP conjugated | Human | ELISA |
DNM1L Proteins
DNM1L Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP007078HU CSB-BP007078HU CSB-MP007078HU CSB-EP007078HU-B |
Recombinant Human Dynamin-1-like protein (DNM1L) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP007078HU | Recombinant Human Dynamin-1-like protein (DNM1L) | E.coli |
DNM1L Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP007078RA CSB-EP007078RA CSB-BP007078RA CSB-MP007078RA CSB-EP007078RA-B |
Recombinant Rat Dynamin-1-like protein (Dnm1l) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DNM1L Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP640665BO CSB-EP640665BO CSB-BP640665BO CSB-MP640665BO CSB-EP640665BO-B |
Recombinant Bovine Dynamin-1-like protein (DNM1L), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DNM1L Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP745817DIL CSB-EP745817DIL CSB-BP745817DIL CSB-MP745817DIL CSB-EP745817DIL-B |
Recombinant Danio rerio Dynamin-1-like protein (dnm1l), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DNM1L Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP816976MO CSB-EP816976MO CSB-BP816976MO CSB-MP816976MO CSB-EP816976MO-B |
Recombinant Mouse Dynamin-1-like protein (Dnm1l) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
