DKK1

DKK1，全稱為Dickkopf-related protein 1，別名包括SK、DKK-1等。該蛋白是一種分泌型糖蛋白，主要由成骨細胞和骨細胞分泌，也表達于胎盤、皮膚、前列腺等多種組織和細胞類型。DKK1通過與Wnt蛋白競爭性結(jié)合LRP5/6受體，拮抗Wnt/β-catenin信號通路活性，從而調(diào)節(jié)細胞增殖、分化及癌變，影響細胞凋亡、瘤細胞侵襲和轉(zhuǎn)移。研究表明，DKK1在不同細胞中表現(xiàn)出相反的調(diào)節(jié)作用，其功能相對復(fù)雜。
在腫瘤發(fā)生發(fā)展中，DKK1的作用呈現(xiàn)多樣性。在某些腫瘤中，如多發(fā)性骨髓瘤、肝細胞癌、非小細胞肺癌等，DKK1表達增高，呈現(xiàn)促癌基因的特征，促進腫瘤生長和轉(zhuǎn)移。而在另一些腫瘤中，如胃癌、膀胱癌、黑色素瘤等，DKK1表達降低，呈現(xiàn)抑癌基因特征，抑制腫瘤生長和轉(zhuǎn)移。此外，DKK1還與帕金森病、強直性脊柱炎、牙周炎等多種疾病有關(guān)。
目前，針對DKK1的藥物研發(fā)取得了一定的進展。多種DKK1抑制劑和調(diào)節(jié)劑處于臨床前或藥物發(fā)現(xiàn)階段，用于治療肝癌、卵巢癌、子宮內(nèi)膜癌、前列腺癌等多種疾病。

熱銷產(chǎn)品

Recombinant Human Dickkopf-related protein 1 (DKK1) (Active) (CSB-MP006920HU(A4))

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human DKK1 at 2 μg/mL can bind Anti-DKK1 recombinant antibody (CSB-RA006920MA1HU), the EC₅₀ is 1.283-2.544 ng/mL.

Recombinant Human Dickkopf-related protein 1 (DKK1), partial Escherichia Coli (CSB-EP006920HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

DKK1 Recombinant Monoclonal Antibody (CSB-RA006920MA1HU)

驗證數(shù)據(jù)

The Binding Activity of Human DKK1 with Anti-DKK1 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DKK1 (CSB-MP006920HU(A4)) at 2 μg/mL can bind Anti-DKK1 recombinant antibody, the EC₅₀ is 1.283-2.544 ng/mL.

Human Dickkopf 1,DKK1 ELISA Kit (CSB-E10104h)

驗證數(shù)據(jù)

貨號：CSB-E10104h

規(guī)格：96T/48T

靈敏度：15.6 pg/mL

檢測范圍：62.5 pg/mL-4000pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

DKK1 Antibody

DKK1 Protein

DKK1 ELISA Kit

DKK1 Antibodies

DKK1 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA006126	DKK1 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA120268	DKK1 Antibody	Human,Mouse	ELISA,WB
CSB-PA06219A0Rb	DKK1 Antibody	Human	ELISA, IHC, IF
CSB-RA576260A0HU	DKK1 Recombinant Monoclonal Antibody	Human	ELISA, WB
CSB-RA006920MA1HU	DKK1 Recombinant Monoclonal Antibody	Human	ELISA

DKK1 Proteins

DKK1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP006920HU CSB-BP006920HU CSB-MP006920HU CSB-EP006920HU-B	Recombinant Human Dickkopf-related protein 1 (DKK1), partial Yeast	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP006920HU	Recombinant Human Dickkopf-related protein 1 (DKK1), partial Escherichia Coli	E.coli
CSB-MP006920HU(A4)	Recombinant Human Dickkopf-related protein 1 (DKK1) (Active)	Mammalian cell

DKK1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP006920MO CSB-EP006920MO CSB-BP006920MO CSB-MP006920MO CSB-EP006920MO-B	Recombinant Mouse Dickkopf-related protein 1 (Dkk1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli