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DHX9

DHX9,全稱為DEAH-box螺旋酶9,常用別名是RNA螺旋酶A(RHA)。這種蛋白具備解開核酸雙鏈的能力,在細(xì)胞內(nèi)參與多項核心生命活動:它能調(diào)控基因的表達(dá)過程,輔助RNA完成加工與運輸,還會與HIV等病毒相互作用,幫助病毒復(fù)制遺傳物質(zhì)。
在疾病方面,DHX9的異常表達(dá)與肺癌、乳腺癌等多種癌癥相關(guān),腫瘤細(xì)胞中它的含量常顯著升高,可能推動腫瘤增殖和擴散;此外,它也可能參與某些自身免疫病的發(fā)病機制。藥物研發(fā)上,目前已有實驗室在探索針對DHX9的小分子抑制劑,這些候選藥物試圖通過抑制其活性來阻斷腫瘤生長或干擾病毒復(fù)制,不過多數(shù)仍處于早期研究階段。

熱銷產(chǎn)品

Recombinant Human ATP-dependent RNA helicase A (DHX9), partial (CSB-EP600078HU)

驗證數(shù)據(jù)

CSB-EP600078HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP600078HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP600078HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) DHX9.

CSB-EP600078HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP600078HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) DHX9.

DHX9 Recombinant Monoclonal Antibody (CSB-RA983870A0HU)

驗證數(shù)據(jù)

CSB-RA983870A0HU

IHC image of CSB-RA983870A0HU diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA983870A0HU

IHC image of CSB-RA983870A0HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA983870A0HU

Immunofluorescence staining of A549 cell with CSB-RA983870A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA983870A0HU

Overlay Peak curve showing Raji cells stained with CSB-RA983870A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

DHX9 Antibody (CSB-PA600078LA01HU)

驗證數(shù)據(jù)

CSB-PA600078LA01HU

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA600078LA01HU at dilution of 1:100

DHX9 Antibodies

DHX9 for Homo sapiens (Human)

DHX9 Proteins

DHX9 Proteins for Homo sapiens (Human)



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