DHODH
DHODH，全稱為二氫乳清酸脫氫酶，是在線粒體中參與嘧啶核苷酸合成的關(guān)鍵酶類，有時(shí)也被簡稱為DHOD。它的核心功能是催化嘧啶合成過程中的關(guān)鍵步驟，為細(xì)胞生成DNA、RNA提供必要的原料，因此與細(xì)胞的生長和分裂過程緊密相關(guān)。
DHODH活性變化會影響細(xì)胞增殖的平衡狀態(tài)，進(jìn)而與多種疾病存在關(guān)聯(lián)：在肺癌、腸癌等多種腫瘤組織中，其表達(dá)水平常顯著升高，助力腫瘤細(xì)胞快速分裂；而在類風(fēng)濕關(guān)節(jié)炎等自身免疫疾病里，它的過度活躍也可能加劇炎癥反應(yīng)的持續(xù)發(fā)展。藥物研發(fā)方面，臨床中常用的來氟米特，其體內(nèi)活性代謝物可通過調(diào)控該蛋白功能緩解類風(fēng)濕關(guān)節(jié)炎癥狀；此外，多款新型靶向藥物正處于研發(fā)階段，嘗試通過精準(zhǔn)作用于它阻斷腫瘤細(xì)胞原料供應(yīng)，部分候選藥物在早期臨床試驗(yàn)中已展現(xiàn)出抑制腫瘤生長的潛力。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
DHODH Antibody (CSB-PA006852LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA006852LA01HU at dilution of 1:100
DHODH Antibodies
DHODH for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006852GA01HU | DHODH Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA007799 | DHODH Antibody | Human | WB, IHC, ELISA |
| CSB-PA006852LA01HU | DHODH Antibody | Human | ELISA, IHC |
| CSB-PA006852LB01HU | DHODH Antibody, HRP conjugated | Human | ELISA |
DHODH Proteins
DHODH Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006852HU CSB-EP006852HU CSB-BP006852HU CSB-MP006852HU CSB-EP006852HU-B |
Recombinant Human Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006852HU1 | Recombinant Human Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH), partial | E.coli |
| CSB-CF006852HU | Recombinant Human Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH) | in vitro E.coli expression system |
| CSB-EP006852HU1b0 | Recombinant Human Dihydroorotate dehydrogenase (quinone),mitochondrial (DHODH), partial | E.coli |
| CSB-EP006852HU1d7 | Recombinant Human Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH), partial | E.coli |
