CTPS1
CTPS1，全稱為胞質(zhì)胸苷酸合成酶1（Cytoplasmic Thymidylate Synthetase 1），是一種參與DNA合成的重要酶。它通過催化dCMP和dATP生成dTTP，為DNA復(fù)制提供必要的核苷三磷酸。CTPS1在細(xì)胞內(nèi)廣泛表達(dá)，并在多種生理過程中發(fā)揮關(guān)鍵作用。由于其在DNA合成中的核心地位，CTPS1的異常表達(dá)或功能失調(diào)與多種疾病相關(guān)，包括癌癥、自身免疫性疾病和代謝性疾病。近年來，CTPS1成為藥物研發(fā)的熱點(diǎn)靶點(diǎn)。研究人員發(fā)現(xiàn)，抑制CTPS1可以減弱腫瘤細(xì)胞的增殖，從而為癌癥治療提供新的策略。此外，CTPS1抑制劑也被研究用于治療自身免疫性疾病和代謝性疾病。目前，已有多種CTPS1抑制劑進(jìn)入臨床試驗(yàn)階段，顯示出良好的治療效果。例如，Step Pharma公司開發(fā)的dencatistat是一種高選擇性、具有口服生物利用度的CTPS1抑制劑，正在開發(fā)用于治療癌癥和血液疾病。研究表明，dencatistat能夠有效抑制腫瘤細(xì)胞的增殖，并提高化療藥物的療效。此外，dencatistat在治療自身免疫性疾病方面也顯示出一定的潛力?？傊?，CTPS1是一種重要的酶，在DNA合成中發(fā)揮關(guān)鍵作用。由于其在多種疾病中的重要作用，CTPS1成為藥物研發(fā)的熱點(diǎn)靶點(diǎn)。目前，已有多種CTPS1抑制劑進(jìn)入臨床試驗(yàn)階段，顯示出良好的治療效果，為相關(guān)疾病的治療提供了新的希望。
熱銷產(chǎn)品
Recombinant Human CTP synthase 1 (CTPS1) (CSB-YP006176HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CTPS1 Recombinant Monoclonal Antibody (CSB-RA699717A0HU)
驗(yàn)證數(shù)據(jù)
Flow cytometric analysis of CTP synthase 1 expression in HT-1080 cells using CTP synthase 1 antibody. Green, isotype control; red, CTP synthase 1.
Western blotting analysis using CTP synthase 1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CTP synthase 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
CTPS1 Antibody (CSB-PA006176LA01HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: CTPS1 antibody at 6µg/ml
Lane 1: Hela whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 67, 42 kDa
Observed band size: 67 kDa
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA006176LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA006176LA01HU at dilution of 1:100
CTPS1 Antibodies
CTPS1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006176GA01HU | CTPS1 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA001828 | CTPS1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA006176LA01HU | CTPS1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA006176LC01HU | CTPS1 Antibody, FITC conjugated | Human | |
| CSB-RA548305A0HU | CTPS1 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
| CSB-RA699717A0HU | CTPS1 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC |
CTPS1 Proteins
CTPS1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006176HU | Recombinant Human CTP synthase 1 (CTPS1) | Yeast |
| CSB-EP006176HU CSB-BP006176HU CSB-MP006176HU CSB-EP006176HU-B |
Recombinant Human CTP synthase 1 (CTPS1) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
