CRBN
CRBN，別名mental retardation, non-syndromic, autosomal recessive, 2A。CRBN是CRL4CRBN E3泛素連接酶復(fù)合物的底物受體，廣泛表達(dá)于多種組織中，尤其在神經(jīng)系統(tǒng)中豐富。CRBN作為底物識(shí)別亞單位，通過與DDB1、Cul4A、ROC1形成E3泛素連接酶復(fù)合物，促進(jìn)目標(biāo)蛋白質(zhì)的泛素化和隨后的蛋白酶體降解，如MEIS2或ILF2。CRBN維持突觸谷氨酸釋放，對(duì)認(rèn)知功能如記憶和學(xué)習(xí)至關(guān)重要，同時(shí)可能通過調(diào)節(jié)BK通道影響焦慮樣行為。CRBN還在TLR4信號(hào)通路中通過與TRAF6和ECSIT相互作用，抑制ECSIT泛素化，從而在信號(hào)傳導(dǎo)中起負(fù)向調(diào)控作用。CRBN的異常功能與多種疾病相關(guān)，包括智力發(fā)展障礙和某些癌癥，同時(shí)也是免疫調(diào)節(jié)藥物如沙利度胺、來那度胺和泊馬度胺的作用靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Protein cereblon (CRBN) (CSB-CF842761HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-CF842761HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CRBN.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-CF842761HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CRBN.
CRBN Antibody (CSB-PA842761ESR1HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: U251 whole cell lysate(30μg), U87 whole cell lysate(30μg), PC-3 whole cell lysate(30μg), SY5Y whole cell lysate(30μg), Mouse Liver tissue lysate(30μg),Mouse Lung tissue lysate(30μg),Mouse Kidney tissue lysate(30μg)
All lanes: CRBN antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 51 kDa
Observed band size: 51 kDa
Exposure time: 120s
CRBN Antibodies
CRBN for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005944GA01HU | CRBN Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA842761ESR1HU | CRBN Antibody | Human, Mouse | ELISA, WB |
| CSB-PA842761ESR2HU | CRBN Antibody | Human, Mouse | ELISA, WB, IHC |
CRBN Proteins
CRBN Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP710067RA CSB-EP710067RA CSB-BP710067RA CSB-MP710067RA CSB-EP710067RA-B |
Recombinant Rat Protein cereblon (Crbn) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF710067RA | Recombinant Rat Protein cereblon (Crbn) | in vitro E.coli expression system |
CRBN Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP806030MO | Recombinant Mouse Protein cereblon (Crbn) | Yeast |
| CSB-EP806030MO CSB-BP806030MO CSB-MP806030MO CSB-EP806030MO-B |
Recombinant Mouse Protein cereblon (Crbn) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CRBN Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP842761HU1 CSB-MP842761HU1 |
Recombinant Human Protein cereblon (CRBN), partial | Yeast Mammalian cell |
| CSB-BP842761HU | Recombinant Human Protein cereblon (CRBN) | Baculovirus |
| CSB-BP842761HUc7 | Recombinant Human Protein cereblon (CRBN) | Baculovirus |
| CSB-EP842761HU1 | Recombinant?Human?Protein?cereblon (CRBN), partial | E.coli |
| CSB-EP842761HU1-B | Recombinant Human Protein cereblon (CRBN), partial, Biotinylated | E.coli |
| CSB-MP842761HU | Recombinant Human Protein cereblon (CRBN) | Mammalian cell |
CRBN Proteins for Homo sapiens(Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-CF842761HU | Recombinant Human Protein cereblon (CRBN) | in vitro E.coli expression system |
| CSB-CF842761HUc7 | Recombinant Human Protein cereblon (CRBN) | in vitro E.coli expression system |
| CSB-CF842761HUa6 | Recombinant Human Protein cereblon (CRBN) | in vitro E.coli expression system |
