CLOCK
CLOCK，別名BMAL1、NPAS2。CLOCK由人類CLOCK基因編碼，該基因位于第四號(hào)染色體的q21.3區(qū)域。CLOCK是一種轉(zhuǎn)錄因子，與BMAL1（BrainandmuscleARNT-like1）形成異源二聚體，共同激活下游的周期基因和BMAL1自身的表達(dá)，從而維持晝夜節(jié)律。CLOCK的作用機(jī)制涉及與BMAL1結(jié)合后，識(shí)別并結(jié)合到靶基因的E-box元件上，促進(jìn)這些基因的轉(zhuǎn)錄。CLOCK對(duì)于調(diào)節(jié)生物的晝夜節(jié)律、睡眠-覺醒周期、代謝以及行為反應(yīng)等具有重要作用。異常的CLOCK表達(dá)與多種生理和病理狀態(tài)相關(guān)，包括睡眠障礙、代謝綜合征和某些神經(jīng)退行性疾病。
熱銷產(chǎn)品
CLOCK Antibody (CSB-PA005574ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: Circadian locomoter output cycles protein kaput antibody at 6μg/ml
Lane 1: Hela whole cell lysate
Lane 2: NIH/3T3 whole cell lysate
Lane 3: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 95 kDa
Observed band size: 95 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA005574ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA005574ESR1HU at dilution of 1:100
CLOCK Antibodies
CLOCK for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005574ESR1HU | CLOCK Antibody | Human | ELISA, WB, IHC |
| CSB-PA001722 | CLOCK Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA005574EA01HU | CLOCK Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA005574EB01HU | CLOCK Antibody, HRP conjugated | Human | ELISA |
CLOCK Proteins
CLOCK Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005574HU CSB-EP005574HU CSB-BP005574HU CSB-MP005574HU CSB-EP005574HU-B |
Recombinant Human Circadian locomoter output cycles protein kaput (CLOCK), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
