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CHI3L1

CHI3L1，全名為軟骨糖蛋白-39或幾丁質(zhì)酶3樣蛋白1，常見別名包括GP39、YKL40和YK-40。該蛋白主要由巨噬細(xì)胞、軟骨細(xì)胞和某些腫瘤細(xì)胞分泌，參與組織重塑、血管生成和神經(jīng)炎癥等多種生物學(xué)過程。CHI3L1在多種神經(jīng)退行性疾病和腦部疾病中發(fā)揮關(guān)鍵作用，如創(chuàng)傷性腦損傷、阿爾茨海默病、帕金森病等，其水平升高與疾病嚴(yán)重性和進(jìn)展密切相關(guān)。研究表明，CHI3L1通過調(diào)節(jié)小膠質(zhì)細(xì)胞和星形膠質(zhì)細(xì)胞的活性，促進(jìn)促炎細(xì)胞因子的釋放，加劇神經(jīng)退行性病理進(jìn)程。此外，CHI3L1還被視為這些疾病的生物標(biāo)志物，并在治療方面展現(xiàn)出潛力。目前，針對(duì)CHI3L1的小分子抑制劑和中和抗體等治療策略已在前臨床研究中顯示出減少神經(jīng)炎癥、改善神經(jīng)元生存的前景，但開發(fā)選擇性和安全的靶向療法仍面臨挑戰(zhàn)。

熱銷產(chǎn)品

Recombinant Human Chitinase-3-like protein 1 (CHI3L1) (CSB-EP005346HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP005346HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CHI3L1.

Human Chitinase-3-like Protein 1(YKL-40/CHI3L1)ELISA Kit (CSB-E13608h)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-E13608h

規(guī)格：96T/48T

靈敏度：78.065 pg/mL

檢測(cè)范圍：46.875 pg/mL-3000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CHI3L1 Protein

CHI3L1 ELISA Kit

CHI3L1 Proteins

CHI3L1 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP005346BO CSB-EP005346BO CSB-BP005346BO CSB-MP005346BO CSB-EP005346BO-B	Recombinant Bovine Chitinase-3-like protein 1 (CHI3L1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CHI3L1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP005346HU CSB-BP005346HU CSB-EP005346HU-B	Recombinant Human Chitinase-3-like protein 1 (CHI3L1)	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP005346HU	Recombinant Human Chitinase-3-like protein 1 (CHI3L1)	E.coli

CHI3L1 Proteins for Sus scrofa (Pig)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP642759PI CSB-EP642759PI CSB-BP642759PI CSB-MP642759PI CSB-EP642759PI-B	Recombinant Pig Chitinase-3-like protein 1 (CHI3L1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CHI3L1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP720246MO CSB-EP720246MO CSB-BP720246MO CSB-MP720246MO CSB-EP720246MO-B	Recombinant Mouse Chitinase-3-like protein 1 (Chi3l1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CHI3L1 Proteins for Pongo abelii (Sumatran orangutan)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP732741PYX CSB-EP732741PYX CSB-BP732741PYX CSB-MP732741PYX CSB-EP732741PYX-B	Recombinant Pongo abelii Chitinase-3-like protein 1 (CHI3L1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CHI3L1 Proteins for Ovis aries (Sheep)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP744230SH CSB-EP744230SH CSB-BP744230SH CSB-MP744230SH CSB-EP744230SH-B	Recombinant Sheep Chitinase-3-like protein 1 (CHI3L1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CHI3L1 Proteins for Bubalus bubalis (Domestic water buffalo)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP767178BWX CSB-EP767178BWX CSB-BP767178BWX CSB-MP767178BWX CSB-EP767178BWX-B	Recombinant Bubalus bubalis Chitinase-3-like protein 1 (CHI3L1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CHI3L1 Proteins for Capra hircus (Goat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP844620GO CSB-EP844620GO CSB-BP844620GO CSB-MP844620GO CSB-EP844620GO-B	Recombinant Goat Chitinase-3-like protein 1 (CHI3L1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CHI3L1 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP893408RA CSB-BP893408RA CSB-MP893408RA CSB-EP893408RA-B	Recombinant Rat Chitinase-3-like protein 1 (Chi3l1)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP893408RAb1	Recombinant Rat Chitinase-3-like protein 1 (Chi3l1)	E.coli
CSB-EP893408RA	Recombinant Rat Chitinase-3-like protein 1 (Chi3l1)	E.coli