CFI

CFI，全稱為補(bǔ)體因子I，常見(jiàn)別名FI，是人體補(bǔ)體系統(tǒng)里的關(guān)鍵調(diào)控者，像一道“安全閥”防止補(bǔ)體過(guò)度激活。它能精準(zhǔn)作用于補(bǔ)體激活產(chǎn)生的C3b、C4b等活性成分，讓這些分子失去繼續(xù)觸發(fā)下游反應(yīng)的能力，從而避免補(bǔ)體系統(tǒng)誤攻擊自身健康細(xì)胞。
CFI功能異常會(huì)引發(fā)多種疾?。夯钚圆蛔銜r(shí)，補(bǔ)體易失控激活，可能導(dǎo)致年齡相關(guān)性黃斑變性（尤其是濕性AMD）、非典型溶血尿毒綜合征（aHUS）、致密物沉積病等；活性過(guò)強(qiáng)則可能降低機(jī)體清除病原體的能力。目前針對(duì)CFI的藥物研發(fā)正穩(wěn)步推進(jìn)，例如部分CFI抑制劑已進(jìn)入臨床試驗(yàn)，用于緩解濕性AMD患者視網(wǎng)膜的炎癥損傷；同時(shí)增強(qiáng)CFI活性的候選藥物也在探索中，有望改善補(bǔ)體缺陷相關(guān)的感染易感性問(wèn)題。

熱銷(xiāo)產(chǎn)品

Recombinant Human Complement factor I (CFI), partial (CSB-EP005279HU1)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CFI Antibody (CSB-PA005279LA01HU)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: HepG2 whole cell lysate, 293 whole cell lysate, Hela whole cell lysate
All lanes: CFI antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 66 kDa
Observed band size: 66 kDa

Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA005279LA01HU at dilution of 1:100

Human complement factor I(CFI) ELISA Kit (CSB-E13108h)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-E13108h

規(guī)格：96T/48T

靈敏度：1.56 ng/mL

檢測(cè)范圍：6.25 ng/mL-400 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CFI Antibody

CFI Protein

CFI ELISA Kit

CFI Antibodies

CFI for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類(lèi)型
CSB-PA564820	CFI Antibody	Human	ELISA,WB
CSB-PA009441	CFI Antibody	Human	WB, ELISA
CSB-PA005279LA01HU	CFI Antibody	Human	ELISA, WB, IHC
CSB-PA005279LB01HU	CFI Antibody, HRP conjugated	Human	ELISA

CFI Proteins

CFI Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP005279HU CSB-BP005279HU CSB-EP005279HU-B	Recombinant Human Complement factor I (CFI)	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP005279HU1	Recombinant Human Complement factor I (CFI), partial	E.coli
CSB-EP005279HU	Recombinant Human Complement factor I (CFI)	E.coli
CSB-MP005279HU	Recombinant Human Complement factor I (CFI)	Mammalian cell
CSB-MP005279HUb0	Recombinant Human Complement factor I (CFI)	Mammalian cell

CFI Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP005279MO1 CSB-EP005279MO1 CSB-EP005279MO1-B	Recombinant Mouse Complement factor I (Cfi), partial	Yeast E.coli In Vivo Biotinylation in E.coli
CSB-BP005279MO	Recombinant Mouse Complement factor I (Cfi)	Baculovirus
CSB-MP005279MO	Recombinant Mouse Complement factor I (Cfi)	Mammalian cell

CFI Proteins for Pongo abelii (Sumatran orangutan)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP005279PYX CSB-EP005279PYX CSB-BP005279PYX CSB-MP005279PYX CSB-EP005279PYX-B	Recombinant Pongo abelii Complement factor I (CFI)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFI Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP005279RA CSB-EP005279RA CSB-EP005279RA-B	Recombinant Rat Complement factor I (Cfi)	Yeast E.coli In Vivo Biotinylation in E.coli
CSB-BP005279RA	Recombinant Rat Complement factor I (Cfi)	Baculovirus
CSB-MP005279RA	Recombinant Rat Complement factor I (Cfi)	Mammalian cell